Inhibition of human platelet mitochondrial protein synthesis by chloramphenicol

G. Agam; M. Djaldetti

Inhibition of human platelet mitochondrial protein synthesis by chloramphenicol

G. Agam, M. Djaldetti

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Human platelet mitochrondial protein synthesis, assayed by 'in vitro' ³H leucine incorporation into the protein moiety of isolated mitochondria, was shown to be inhibited by a therapeutic concentration of chloramphenical (CAP). This finding is in accordance with the ultrastructural damage caused to these organelles by the antibiotic, and with the inhibition of mitochondrial protein synthesis found in other kinds of mammalian cells.

Original language	English
Pages (from-to)	66-69
Number of pages	4
Journal	Biomedicine Express
Volume	27
Issue number	2
State	Published - 1 Jan 1977
Externally published	Yes

ASJC Scopus subject areas

General Medicine

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Cite this

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title = "Inhibition of human platelet mitochondrial protein synthesis by chloramphenicol",

abstract = "Human platelet mitochrondial protein synthesis, assayed by 'in vitro' 3H leucine incorporation into the protein moiety of isolated mitochondria, was shown to be inhibited by a therapeutic concentration of chloramphenical (CAP). This finding is in accordance with the ultrastructural damage caused to these organelles by the antibiotic, and with the inhibition of mitochondrial protein synthesis found in other kinds of mammalian cells.",

author = "G. Agam and M. Djaldetti",

year = "1977",

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language = "English",

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T1 - Inhibition of human platelet mitochondrial protein synthesis by chloramphenicol

AU - Agam, G.

AU - Djaldetti, M.

PY - 1977/1/1

Y1 - 1977/1/1

N2 - Human platelet mitochrondial protein synthesis, assayed by 'in vitro' 3H leucine incorporation into the protein moiety of isolated mitochondria, was shown to be inhibited by a therapeutic concentration of chloramphenical (CAP). This finding is in accordance with the ultrastructural damage caused to these organelles by the antibiotic, and with the inhibition of mitochondrial protein synthesis found in other kinds of mammalian cells.

AB - Human platelet mitochrondial protein synthesis, assayed by 'in vitro' 3H leucine incorporation into the protein moiety of isolated mitochondria, was shown to be inhibited by a therapeutic concentration of chloramphenical (CAP). This finding is in accordance with the ultrastructural damage caused to these organelles by the antibiotic, and with the inhibition of mitochondrial protein synthesis found in other kinds of mammalian cells.

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M3 - Article

AN - SCOPUS:0017325844

SN - 0300-0885

VL - 27

SP - 66

EP - 69

JO - Biomedicine Express

JF - Biomedicine Express

IS - 2

ER -

Inhibition of human platelet mitochondrial protein synthesis by chloramphenicol

Abstract

ASJC Scopus subject areas

UN SDGs

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