Inhibition of Rickettsia conorii growth by recombinant tumor necrosis factor alpha: Enhancement of inhibition by gamma interferon

E. Manor, I. Sarov

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20 Scopus citations

Abstract

Purified human recombinant tumor necrosis factor alpha (rTNF-α) inhibited the growth of Rickettsia conorii (Casablanca strain) in HEp-2 cell culture. The effect was observed when the cells were pretreated with rTNF-α or when rTNF-α was added after adsorption of the rickettsiae. The inhibitory effect of rTNF-α on rickettsial growth was enhanced by gamma interferon. Cycloheximide had no effect on inhibition of the rickettsial yield, suggesting that de novo protein synthesis is not required for the inhibitory effect of rTNF-α. The addition of tryptophan partially abolished the inhibitory effect of rTNF-α and rTNF-α plus gamma interferon

Original languageEnglish
Pages (from-to)1886-1890
Number of pages5
JournalInfection and Immunity
Volume58
Issue number6
StatePublished - 1 Jan 1990

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