Initial experience of videocapsule endoscopy for diagnosing small-bowel tumors in patients with GI polyposis syndromes

Olga Barkay, Menachem Moshkowitz, Zvi Fireman, Eliahu Shemesh, Orit Goldray, Miri Revivo, Ada Kessler, Zamir Halpern, Avi Orr-Urtreger, Nadir Arber

    Research output: Contribution to journalArticlepeer-review

    37 Scopus citations

    Abstract

    Background: Small-bowel tumors frequently occur in familial adenomatous polyposis and other GI polyposis syndromes. These tumors are difficult to detect with conventional techniques. Our aim was to assess the utility of videocapsule endoscopy in the detection of small-bowel tumors in this setting. Methods: We examined 19 familial adenomatous polyposis patients and 3 patients with either Peutz-Jeghers syndrome, hyperplastic polyposis, or Cowden disease. Observations: Prevalence of small-bowel polyps on videocapsule endoscopy was 59% in all patients, 52.6% in familial adenomatous polyposis patients, and 75% in a subgroup of familial adenomatous polyposis patients with exon 15 mutations. Videocapsule endoscopy was safe and well tolerated in all patients. Conclusions: Videocapsule endoscopy has a high yield in detecting small-bowel tumors in patients with GI polyposis syndromes. It may be especially indicated in familial adenomatous polyposis patients with the aggressive phenotype of the disease, e.g., mutations in exon 15.

    Original languageEnglish
    Pages (from-to)448-452
    Number of pages5
    JournalGastrointestinal Endoscopy
    Volume62
    Issue number3
    DOIs
    StatePublished - 1 Sep 2005

    ASJC Scopus subject areas

    • Radiology Nuclear Medicine and imaging
    • Gastroenterology

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