Innovative uses for zinc in dermatology

Yoon Soo Bae, Nikki D. Hill, Yuval Bibi, Jacob Dreiher, Arnon D. Cohen

Research output: Contribution to journalReview articlepeer-review

29 Scopus citations

Abstract

Severe zinc deficiency states, such as acrodermatitis enteropathica, are associated with a variety of skin manifestations, such as perioral, acral, and perineal dermatitis. These syndromes can be reversed with systemic zinc repletion. In addition to skin pathologies that are clearly zinc-dependent, many dermatologic conditions (eg, dandruff, acne, and diaper rash) have been associated and treated with zinc. Success rates for treatment with zinc vary greatly depending on the disease, mode of administration, and precise zinc preparation used. With the exception of systemic zinc deficiency states, there is little evidence that convincingly demonstrates the efficacy of zinc as a reliable first-line treatment for most dermatologic conditions. However, zinc may be considered as an adjunctive treatment modality. Further research is needed to establish the indications for zinc treatment in dermatology, optimal mode of zinc delivery, and best type of zinc compound to be used.

Original languageEnglish
Pages (from-to)587-597
Number of pages11
JournalDermatologic Clinics
Volume28
Issue number3
DOIs
StatePublished - 1 Jul 2010

Keywords

  • Dermatology
  • Zinc
  • Zinc deficiency

ASJC Scopus subject areas

  • Dermatology

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