Inositol 6 g daily may be effective in depression but not in schizophrenia

Joseph Levine, Mirtha Gonsalves, Izak Babur, Shaul Stier, Avner Elizur, Ora Kofman, R. H. Belmaker

Research output: Contribution to journalArticlepeer-review

38 Scopus citations


Inositol is an important precursor for second messenger synthesis and has been reported to be reduced by lithium treatment in rat brain and in human CSF in depression. An open trial of 6 g/day in 11 depressed patients resistant to previous treatment led to major improvement in nine patients. The enzyme synthesizing inositol has been reported to be elevated in schizophrenia, suggesting an attempted compensation for possible inositol deficiency. A controlled double‐blind crossover trial in 10 chronic schizophrenic patients of 6 g/day of inositol for 30 days did not reveal any benefit.

Original languageEnglish
Pages (from-to)49-53
Number of pages5
JournalHuman Psychopharmacology
Issue number1
StatePublished - 1 Jan 1993


  • Inositol
  • depression
  • schizophrenia

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health
  • Pharmacology (medical)


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