Inositol has behavioral effects with adaptation after chronic administration

H. Cohen, M. Kotler, Z. Kaplan, M. A. Matar, O. Kofman, R. H. Belmaker

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


Inositol is a simple dietary polyol that serves as a precursor in important second messenger systems. Inositol in pharmacological doses has been reported recently to be therapeutic in depression, panic disorder and obsessive compulsive disorder. We hereby report effects of inositol in the elevated plus maze model of anxiety. These results should allow development of new inositol analogs that could expand psychoactive drug development possibilities via second messenger manipulation.

Original languageEnglish
Pages (from-to)299-305
Number of pages7
JournalJournal of Neural Transmission
Issue number2-3
StatePublished - 1 Jan 1997


  • Animal model
  • Anxiety
  • Inositol
  • PI cycle

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health
  • Biological Psychiatry


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