Inositol monophosphatase activity in brain and lymphocyte-derived ceii lines of bipolar patients

Galit Shaltiel, Alon Shamir, Lubov Nemanov, Yuri Yaroslavsky, Boris Nemets, Richard P. Ebstein, Robert H. Belmaker, Galila Agam

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

Background: Inositol monophosphatase (IMPase) activity was reported to be low in lymphocyte-derived cell lines of bipolar patients. Methods: IMPase activity was measured spectrophotometrically as inorganic phosphate liberated from inositol-1-phosphate. Results: The previously reported reduction was replicated in a new, small group of bipolar patients. The reduction is not present in cell lines of unipolar or schizophrenic patients. IMPase activity in postmortem frontal and occipital cortical samples of unipolar, bipolar and schizophrenic patients was not different from controls. Conclusions: A reduction in lymphocyte-derived IMPase activity without a parallel reduction in cortical IMPase activity could be due to the fact that most leukocyte IMPase activity is the product of the IMPA-2 gene.

Original languageEnglish
Pages (from-to)95-98
Number of pages4
JournalWorld Journal of Biological Psychiatry
Volume2
Issue number2
DOIs
StatePublished - 1 Dec 2001

Keywords

  • bipolar disorder
  • enzyme activity
  • inositol monophosphatase (IMPase)
  • lymphcytederived cell lines
  • postmortem brain

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

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