Inositol treatment raises CSF inositol levels

J. Levine, A. Rapaport, L. Lev, Y. Bersudsky, O. Kofman, R. H. Belmaker, J. Shapiro, G. Agam

Research output: Contribution to journalArticlepeer-review

61 Scopus citations


Inositol is a key precursor for synthesis of phosphatidylinositol in a major second messenger signalling system. It is biologically active in syndromes such as respiratory distress syndrome but has been thought to be excluded from CNS by the blood-strain barrier. Oral inositol treatment of 8 patients is shown to significantly increase CSF inositol by almost 70%, suggesting possible CNS therapeutic applications of this compound and possible CNS side-effects of systemic therapy.

Original languageEnglish
Pages (from-to)168-170
Number of pages3
JournalBrain Research
Issue number1
StatePublished - 5 Nov 1993


  • Blood-brain barrier
  • Cerebrospinal fluid
  • Inositol
  • Second messenger

ASJC Scopus subject areas

  • Neuroscience (all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology


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