Inositol treatment raises CSF inositol levels

J. Levine; A. Rapaport; L. Lev; Y. Bersudsky; O. Kofman; R. H. Belmaker; J. Shapiro; G. Agam

doi:10.1016/0006-8993(93)90761-B

Inositol treatment raises CSF inositol levels

J. Levine, A. Rapaport, L. Lev, Y. Bersudsky, O. Kofman, R. H. Belmaker, J. Shapiro, G. Agam

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61 Scopus citations

Abstract

Inositol is a key precursor for synthesis of phosphatidylinositol in a major second messenger signalling system. It is biologically active in syndromes such as respiratory distress syndrome but has been thought to be excluded from CNS by the blood-strain barrier. Oral inositol treatment of 8 patients is shown to significantly increase CSF inositol by almost 70%, suggesting possible CNS therapeutic applications of this compound and possible CNS side-effects of systemic therapy.

Original language	English
Pages (from-to)	168-170
Number of pages	3
Journal	Brain Research
Volume	627
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(93)90761-B
State	Published - 5 Nov 1993

Keywords

Blood-brain barrier
Cerebrospinal fluid
Inositol
Second messenger

ASJC Scopus subject areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/0006-8993(93)90761-B

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title = "Inositol treatment raises CSF inositol levels",

abstract = "Inositol is a key precursor for synthesis of phosphatidylinositol in a major second messenger signalling system. It is biologically active in syndromes such as respiratory distress syndrome but has been thought to be excluded from CNS by the blood-strain barrier. Oral inositol treatment of 8 patients is shown to significantly increase CSF inositol by almost 70%, suggesting possible CNS therapeutic applications of this compound and possible CNS side-effects of systemic therapy.",

keywords = "Blood-brain barrier, Cerebrospinal fluid, Inositol, Second messenger",

author = "J. Levine and A. Rapaport and L. Lev and Y. Bersudsky and O. Kofman and Belmaker, {R. H.} and J. Shapiro and G. Agam",

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T1 - Inositol treatment raises CSF inositol levels

AU - Levine, J.

AU - Rapaport, A.

AU - Lev, L.

AU - Bersudsky, Y.

AU - Kofman, O.

AU - Belmaker, R. H.

AU - Shapiro, J.

AU - Agam, G.

PY - 1993/11/5

Y1 - 1993/11/5

N2 - Inositol is a key precursor for synthesis of phosphatidylinositol in a major second messenger signalling system. It is biologically active in syndromes such as respiratory distress syndrome but has been thought to be excluded from CNS by the blood-strain barrier. Oral inositol treatment of 8 patients is shown to significantly increase CSF inositol by almost 70%, suggesting possible CNS therapeutic applications of this compound and possible CNS side-effects of systemic therapy.

AB - Inositol is a key precursor for synthesis of phosphatidylinositol in a major second messenger signalling system. It is biologically active in syndromes such as respiratory distress syndrome but has been thought to be excluded from CNS by the blood-strain barrier. Oral inositol treatment of 8 patients is shown to significantly increase CSF inositol by almost 70%, suggesting possible CNS therapeutic applications of this compound and possible CNS side-effects of systemic therapy.

KW - Blood-brain barrier

KW - Cerebrospinal fluid

KW - Inositol

KW - Second messenger

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U2 - 10.1016/0006-8993(93)90761-B

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JO - Brain Research

JF - Brain Research

IS - 1

ER -

Inositol treatment raises CSF inositol levels

Abstract

Keywords

ASJC Scopus subject areas

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