Insight into the functional organization of nuclear lamins in health and disease

Meltem Tatli, Ohad Medalia

Research output: Contribution to journalReview articlepeer-review

24 Scopus citations

Abstract

Lamins are the main component of the nuclear lamina, a protein meshwork at the inner nuclear membrane which primarily provide mechanical stability to the nucleus. Lamins, type V intermediate filament proteins, are also involved in many nuclear activities. Structural analysis of nuclei revealed that lamins form 3.5 nm thick filaments often interact with nuclear pore complexes. Mutations in the LMNA gene, encoding A-type lamins, have been associated with at least 15 distinct diseases collectively termed laminopathies, including muscle, metabolic and neurological disorders, and premature aging syndrome. It is unclear how laminopathic mutations lead to such a wide array of diseases, essentially affecting almost all tissues.

Original languageEnglish
Pages (from-to)72-79
Number of pages8
JournalCurrent Opinion in Cell Biology
Volume54
DOIs
StatePublished - 1 Oct 2018

ASJC Scopus subject areas

  • Cell Biology

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