Installation and testing of an optimized epithermal neutron beam at the Brookhaven Medical Research Reactor (BMRR).

R. G. Fairchild; J. Kalef-Ezra; S. K. Saraf; S. Fiarman; E. Ramsey; L. Wielopolski; B. H. Laster; F. J. Wheeler

doi:10.1007/978-1-4684-5802-2_14

Installation and testing of an optimized epithermal neutron beam at the Brookhaven Medical Research Reactor (BMRR).

R. G. Fairchild, J. Kalef-Ezra, S. K. Saraf, S. Fiarman, E. Ramsey, L. Wielopolski, B. H. Laster, F. J. Wheeler

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Abstract

NCT is a binary system, in which 10B is physiologically targeted to tumor and then allowed to interact with thermal neutrons generated in the treatment volume by an externally applied neutron beam. Consequently, an unusually large number of parameters are obtained, which bear on the resultant Therapeutic Gain (TG). However, a perusal of these data, as illustrated in Figure 7, indicates that the TG would increase significantly beyond values projected in this paper if the absolute amount of 10B could be increased above 30 ppm. For example, increasing 10B concentration in tumor to 45 ppm would increase TG by approximately 33% (with a T/N of 5). A similar increase in TG would follow an increase in T/N from 5 to 10. Those associated with the development of boron compounds for NCT feel that such developments are within reach.

Original language	English
Pages (from-to)	185-199
Number of pages	15
Journal	Basic Life Sciences
Volume	54
DOIs	https://doi.org/10.1007/978-1-4684-5802-2_14
State	Published - 1 Jan 1990
Externally published	Yes

ASJC Scopus subject areas

General Medicine

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10.1007/978-1-4684-5802-2_14

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title = "Installation and testing of an optimized epithermal neutron beam at the Brookhaven Medical Research Reactor (BMRR).",

abstract = "NCT is a binary system, in which 10B is physiologically targeted to tumor and then allowed to interact with thermal neutrons generated in the treatment volume by an externally applied neutron beam. Consequently, an unusually large number of parameters are obtained, which bear on the resultant Therapeutic Gain (TG). However, a perusal of these data, as illustrated in Figure 7, indicates that the TG would increase significantly beyond values projected in this paper if the absolute amount of 10B could be increased above 30 ppm. For example, increasing 10B concentration in tumor to 45 ppm would increase TG by approximately 33% (with a T/N of 5). A similar increase in TG would follow an increase in T/N from 5 to 10. Those associated with the development of boron compounds for NCT feel that such developments are within reach.",

author = "Fairchild, {R. G.} and J. Kalef-Ezra and Saraf, {S. K.} and S. Fiarman and E. Ramsey and L. Wielopolski and Laster, {B. H.} and Wheeler, {F. J.}",

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T1 - Installation and testing of an optimized epithermal neutron beam at the Brookhaven Medical Research Reactor (BMRR).

AU - Fairchild, R. G.

AU - Kalef-Ezra, J.

AU - Saraf, S. K.

AU - Fiarman, S.

AU - Ramsey, E.

AU - Wielopolski, L.

AU - Laster, B. H.

AU - Wheeler, F. J.

PY - 1990/1/1

Y1 - 1990/1/1

N2 - NCT is a binary system, in which 10B is physiologically targeted to tumor and then allowed to interact with thermal neutrons generated in the treatment volume by an externally applied neutron beam. Consequently, an unusually large number of parameters are obtained, which bear on the resultant Therapeutic Gain (TG). However, a perusal of these data, as illustrated in Figure 7, indicates that the TG would increase significantly beyond values projected in this paper if the absolute amount of 10B could be increased above 30 ppm. For example, increasing 10B concentration in tumor to 45 ppm would increase TG by approximately 33% (with a T/N of 5). A similar increase in TG would follow an increase in T/N from 5 to 10. Those associated with the development of boron compounds for NCT feel that such developments are within reach.

AB - NCT is a binary system, in which 10B is physiologically targeted to tumor and then allowed to interact with thermal neutrons generated in the treatment volume by an externally applied neutron beam. Consequently, an unusually large number of parameters are obtained, which bear on the resultant Therapeutic Gain (TG). However, a perusal of these data, as illustrated in Figure 7, indicates that the TG would increase significantly beyond values projected in this paper if the absolute amount of 10B could be increased above 30 ppm. For example, increasing 10B concentration in tumor to 45 ppm would increase TG by approximately 33% (with a T/N of 5). A similar increase in TG would follow an increase in T/N from 5 to 10. Those associated with the development of boron compounds for NCT feel that such developments are within reach.

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Installation and testing of an optimized epithermal neutron beam at the Brookhaven Medical Research Reactor (BMRR).

Abstract

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