Insulin signaling modulates border cell movement in drosophila oogenesis

Aditi Sharma, Sudipta Halder, Martina Felix, Khairun Nisaa, Girish Deshpande, Mohit Prasad

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


As collective cell migration is intimately involved in different aspects of metazoan development, molecular mechanisms underlying this process are being explored in a variety of developmental contexts. Border cell (BC) migration during Drosophila oogenesis has emerged as an excellent genetic model for studying collective cell migration. BCs are of epithelial origin but acquire partial mesenchymal characteristics before migrating as a group towards the oocyte. Here, we report that insulin signaling modulates collective BC movement during Drosophila oogenesis. Supporting the involvement of Insulin pathway, we demonstrate that compromising Insulin-like Receptor (InR) levels in BCs, inhibits their migration. Furthermore, we show that canonical Insulin signaling pathway components participate in this process. Interestingly, visualization of InR-depleted BC clusters, using time-lapse imaging, revealed a delay in detachment of BC clusters from the surrounding anterior follicle cells and altered protrusion dynamics. Lastly, based on genetic interactions between InR, the polarity determinant, par-1 and a regulatory subunit of Drosophila Myosin (spaghetti squash), we propose that Insulin signaling likely influences par-1 activity to engineer border cell detachment and subsequent movement via Drosophila Myosin.

Original languageEnglish
Article numberdev166165
JournalDevelopment (Cambridge)
Issue number14
StatePublished - 15 Jul 2018
Externally publishedYes


  • Border cell migration
  • Drosophila oogenesis
  • Insulin signaling
  • Myo II
  • PAR-1

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology


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