TY - GEN
T1 - Integration of RNA search methods for identifying novel riboswitch patterns in eukaryotes
AU - Cohen, Adaya N.
AU - Kedem, Klara
AU - Shapira, Michal
AU - Barash, Danny
PY - 2005/12/1
Y1 - 2005/12/1
N2 - Riboswitches are RNA genetic control elements that were recently discovered in living cells. To regulate gene expression, they utilize a unique mechanism whereby small molecules bind to the aptamer or box region causing a conformational switch, without the participation of proteins. Riboswitches were initially found in the 5' UTR of bacteria, with successive discoveries in prokaryotes. Evidence for their existence in eukaryotes has prompted their scarce detection in that kingdom. Bioinformatics methods are needed in order to locate new riboswitch candidates. Several relevant search strategies have been developed and investigated, each having its own advantages and deficiencies. By merging several of these methods and integrating them in a hierarchical manner, it is possible to develop a combined strategy that will successfully locate potential candidates for the purpose of experimental validation.
AB - Riboswitches are RNA genetic control elements that were recently discovered in living cells. To regulate gene expression, they utilize a unique mechanism whereby small molecules bind to the aptamer or box region causing a conformational switch, without the participation of proteins. Riboswitches were initially found in the 5' UTR of bacteria, with successive discoveries in prokaryotes. Evidence for their existence in eukaryotes has prompted their scarce detection in that kingdom. Bioinformatics methods are needed in order to locate new riboswitch candidates. Several relevant search strategies have been developed and investigated, each having its own advantages and deficiencies. By merging several of these methods and integrating them in a hierarchical manner, it is possible to develop a combined strategy that will successfully locate potential candidates for the purpose of experimental validation.
UR - http://www.scopus.com/inward/record.url?scp=33749046707&partnerID=8YFLogxK
U2 - 10.1109/CSBW.2005.78
DO - 10.1109/CSBW.2005.78
M3 - Conference contribution
AN - SCOPUS:33749046707
SN - 0769524427
SN - 9780769524429
T3 - 2005 IEEE Computational Systems Bioinformatics Conference, Workshops and Poster Abstracts
SP - 193
EP - 194
BT - 2005 IEEE Computational Systems Bioinformatics Conference, Workshops and Poster Abstracts
T2 - 2005 IEEE Computational Systems Bioinformatics Conference, Workshops and Poster Abstracts
Y2 - 8 August 2005 through 11 August 2005
ER -