Integration of RNA search methods for identifying novel riboswitch patterns in eukaryotes

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Riboswitches are RNA genetic control elements that were recently discovered in living cells. To regulate gene expression, they utilize a unique mechanism whereby small molecules bind to the aptamer or box region causing a conformational switch, without the participation of proteins. Riboswitches were initially found in the 5' UTR of bacteria, with successive discoveries in prokaryotes. Evidence for their existence in eukaryotes has prompted their scarce detection in that kingdom. Bioinformatics methods are needed in order to locate new riboswitch candidates. Several relevant search strategies have been developed and investigated, each having its own advantages and deficiencies. By merging several of these methods and integrating them in a hierarchical manner, it is possible to develop a combined strategy that will successfully locate potential candidates for the purpose of experimental validation.

Original languageEnglish
Title of host publication2005 IEEE Computational Systems Bioinformatics Conference, Workshops and Poster Abstracts
Pages193-194
Number of pages2
DOIs
StatePublished - 1 Dec 2005
Event2005 IEEE Computational Systems Bioinformatics Conference, Workshops and Poster Abstracts - Stanford, CA, United States
Duration: 8 Aug 200511 Aug 2005

Publication series

Name2005 IEEE Computational Systems Bioinformatics Conference, Workshops and Poster Abstracts

Conference

Conference2005 IEEE Computational Systems Bioinformatics Conference, Workshops and Poster Abstracts
Country/TerritoryUnited States
CityStanford, CA
Period8/08/0511/08/05

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