Intelligent Multi-Electrode Array for Real-Time Treatment Monitoring of Antipsychotic Clozapine

Rajendra P. Shukla, Deanna L. Kelly, Hadar Ben-Yoav

Research output: Contribution to conferenceAbstract


Schizophrenia is a challenging mental health disorder [1]. While various antipsychotics have been used to treat schizophrenia, monitoring schizophrenia treatment requires patients to frequently travel to hospitals in order to test and maintain efficacious levels. Yet, current technologies for antipsychotic drug monitoring require benchtop equipment and long sample preparation times, impeding the ability to rapidly measure various antipsychotics levels at the point-of-care. For example, clozapine is the most effective antipsychotic medication for schizophrenia, but it is dramatically underutilized due to a burdensome monitoring scheme. We propose to overcome the analytical challenges by designing an intelligent multi-sensor array that will be modified with micro/nanometer-thick films [2]. The films are based on 2D materials (reduced graphene oxide, MoS2 and WS2) that increase the electrocatalytic activity of the sensors and the underlying variability of the electrochemical signals generated by the antipsychotics. Here, we have shown, (1) the development of microelectrodes modified with 2D materials, (2) the development of an intelligent multi-electrode array framework, and (3) the proof-of-concept extraction of antipsychotic levels from schizophrenia patients by using intelligent chemometric models (Figure 1). By rapidly deciphering the electrochemical signals in whole blood and quantifying the levels of the antipsychotics, better schizophrenia treatment outcome can be enabled.
Original languageEnglish
StatePublished - 1 Jan 2020
Event7th International Electronic Conference on Sensors and Applications -
Duration: 15 Nov 202030 Nov 2020


Conference7th International Electronic Conference on Sensors and Applications

ASJC Scopus subject areas

  • Biomedical Engineering
  • Electrical and Electronic Engineering
  • Industrial and Manufacturing Engineering
  • Mechanical Engineering


Dive into the research topics of 'Intelligent Multi-Electrode Array for Real-Time Treatment Monitoring of Antipsychotic Clozapine'. Together they form a unique fingerprint.

Cite this