Interaction of alfalfa saponins with components of the erythrocyte membrane in hemolysis

Y. Assa; S. Shany; B. Gestetner; Y. Tencer; Y. Birk; A. Bondi

doi:10.1016/0005-2736(73)90027-8

Interaction of alfalfa saponins with components of the erythrocyte membrane in hemolysis

Y. Assa, S. Shany, B. Gestetner, Y. Tencer, Y. Birk, A. Bondi

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

The interactions of saponins with erythrocyte membrane components involved in the hemolytic mechanism were studied. It was found that the alfalfa saponin, medicagenic acid 3-β-O-triglucoside, forms interaction products of different stability with membrane cholesterol, proteins and phospholipids. The resulting structural changes affect only slightly the membranous enzyme activities examined. It is suggested that breakdown of the structure of the membrane stems from a combination of non-specific interactions of saponins with membrane proteins phospholipids and cholesterol leading consequently to hemolysis.

Original language	English
Pages (from-to)	83-91
Number of pages	9
Journal	Biochimica et Biophysica Acta - Biomembranes
Volume	307
Issue number	1
DOIs	https://doi.org/10.1016/0005-2736(73)90027-8
State	Published - 25 Apr 1973
Externally published	Yes

ASJC Scopus subject areas

Biophysics
Biochemistry
Cell Biology

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abstract = "The interactions of saponins with erythrocyte membrane components involved in the hemolytic mechanism were studied. It was found that the alfalfa saponin, medicagenic acid 3-β-O-triglucoside, forms interaction products of different stability with membrane cholesterol, proteins and phospholipids. The resulting structural changes affect only slightly the membranous enzyme activities examined. It is suggested that breakdown of the structure of the membrane stems from a combination of non-specific interactions of saponins with membrane proteins phospholipids and cholesterol leading consequently to hemolysis.",

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AU - Assa, Y.

AU - Shany, S.

AU - Gestetner, B.

AU - Tencer, Y.

AU - Birk, Y.

AU - Bondi, A.

PY - 1973/4/25

Y1 - 1973/4/25

N2 - The interactions of saponins with erythrocyte membrane components involved in the hemolytic mechanism were studied. It was found that the alfalfa saponin, medicagenic acid 3-β-O-triglucoside, forms interaction products of different stability with membrane cholesterol, proteins and phospholipids. The resulting structural changes affect only slightly the membranous enzyme activities examined. It is suggested that breakdown of the structure of the membrane stems from a combination of non-specific interactions of saponins with membrane proteins phospholipids and cholesterol leading consequently to hemolysis.

AB - The interactions of saponins with erythrocyte membrane components involved in the hemolytic mechanism were studied. It was found that the alfalfa saponin, medicagenic acid 3-β-O-triglucoside, forms interaction products of different stability with membrane cholesterol, proteins and phospholipids. The resulting structural changes affect only slightly the membranous enzyme activities examined. It is suggested that breakdown of the structure of the membrane stems from a combination of non-specific interactions of saponins with membrane proteins phospholipids and cholesterol leading consequently to hemolysis.

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JF - Biochimica et Biophysica Acta - Biomembranes

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ER -

Interaction of alfalfa saponins with components of the erythrocyte membrane in hemolysis

Abstract

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