Interaction of Ca-channel blockers and high pressure at the crustacean neuromuscular junction

Yoram Grossman; Joel S. Colton; Sara C. Gilman

doi:10.1016/0304-3940(91)90129-H

Interaction of Ca-channel blockers and high pressure at the crustacean neuromuscular junction

Yoram Grossman, Joel S. Colton, Sara C. Gilman

Physiology and Cell Biology

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Exposure to high pressure causes a significant depression of synaptic transmission. We examined the effects of various Ca-channel blockers and their interaction with high pressure on excitatory neuromuscular junction currents (EJCs) of lobster abdominal muscles. Reduced [Ca²⁺]_o to half of normal concentration or exposure to 40-60 μM CdCl₂, 10-20 μM NiCl₂ and 1 μM ω-conotoxin decreased EJCs by 50%. Nifedipine, Nitrendipine and Bay K-8644 were ineffective. Either Ca-blockers or reduced [Ca²⁺]_o, enhanced EJC suppression exerted by high pressure. The data suggest that high pressure primarily affects Ca²⁺ inflow at the presynaptic terminals through N-type voltage-gated Ca-channel.

Original language	English
Pages (from-to)	53-56
Number of pages	4
Journal	Neuroscience Letters
Volume	125
Issue number	1
DOIs	https://doi.org/10.1016/0304-3940(91)90129-H
State	Published - 15 Apr 1991

Keywords

Ca-channel
Crustacea
High pressure
Hyperbaric condition
Junctional current
Transmitter release

ASJC Scopus subject areas

General Neuroscience

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10.1016/0304-3940(91)90129-H

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abstract = "Exposure to high pressure causes a significant depression of synaptic transmission. We examined the effects of various Ca-channel blockers and their interaction with high pressure on excitatory neuromuscular junction currents (EJCs) of lobster abdominal muscles. Reduced [Ca2+]o to half of normal concentration or exposure to 40-60 μM CdCl2, 10-20 μM NiCl2 and 1 μM ω-conotoxin decreased EJCs by 50%. Nifedipine, Nitrendipine and Bay K-8644 were ineffective. Either Ca-blockers or reduced [Ca2+]o, enhanced EJC suppression exerted by high pressure. The data suggest that high pressure primarily affects Ca2+ inflow at the presynaptic terminals through N-type voltage-gated Ca-channel.",

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AU - Colton, Joel S.

AU - Gilman, Sara C.

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N2 - Exposure to high pressure causes a significant depression of synaptic transmission. We examined the effects of various Ca-channel blockers and their interaction with high pressure on excitatory neuromuscular junction currents (EJCs) of lobster abdominal muscles. Reduced [Ca2+]o to half of normal concentration or exposure to 40-60 μM CdCl2, 10-20 μM NiCl2 and 1 μM ω-conotoxin decreased EJCs by 50%. Nifedipine, Nitrendipine and Bay K-8644 were ineffective. Either Ca-blockers or reduced [Ca2+]o, enhanced EJC suppression exerted by high pressure. The data suggest that high pressure primarily affects Ca2+ inflow at the presynaptic terminals through N-type voltage-gated Ca-channel.

AB - Exposure to high pressure causes a significant depression of synaptic transmission. We examined the effects of various Ca-channel blockers and their interaction with high pressure on excitatory neuromuscular junction currents (EJCs) of lobster abdominal muscles. Reduced [Ca2+]o to half of normal concentration or exposure to 40-60 μM CdCl2, 10-20 μM NiCl2 and 1 μM ω-conotoxin decreased EJCs by 50%. Nifedipine, Nitrendipine and Bay K-8644 were ineffective. Either Ca-blockers or reduced [Ca2+]o, enhanced EJC suppression exerted by high pressure. The data suggest that high pressure primarily affects Ca2+ inflow at the presynaptic terminals through N-type voltage-gated Ca-channel.

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Interaction of Ca-channel blockers and high pressure at the crustacean neuromuscular junction

Abstract

Keywords

ASJC Scopus subject areas

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