Interactions of polyphenols with plasma proteins: Insights from analytical techniques

Seetharamappa Jaldappagari, Sandhya Balakrishnan, Ashwini H. Hegde, Nagappa L. Teradal, Prashanth S. Narayan

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


Phenolic compounds are commonly found in natural sources like plant-based foods and beverages. These compounds have received much attention due to their unique biological properties. Polyphenols possess a significant binding affinity for serum albumins which are known to be principal extracellular proteins with a high concentration in blood plasma. They act as carriers of several drugs to different molecular targets. This review summarizes the salient features of the reported work on polyphenol-protein interactions by analytical methods viz., chromatography, circular dichroism, fluorescence spectroscopy (steady state and time resolved), light scattering, equilibrium dialysis, differential scanning calorimetry, UV-vis spectroscopy, isothermal calorimetry, MALDI-TOF mass spectrometry, size exclusion chromatography, capillary electrophoresis, electrospray ionization mass spectrometry, FT-IR, molecular modelling, HPLC, NMR, cyclic voltammetry etc. Polyphenol-serum albumin interaction studies assume significance from the view point of pharmacokinet-ics and pharmacodynamics.

Original languageEnglish
Pages (from-to)456-473
Number of pages18
JournalCurrent Drug Metabolism
Issue number4
StatePublished - 1 May 2013
Externally publishedYes


  • Analytical methods
  • Interactions
  • Polyphenols
  • Serum albumins

ASJC Scopus subject areas

  • Pharmacology
  • Clinical Biochemistry


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