Interchangeability of 2 diphtheria-tetanus-acellular pertussis vaccines in infancy

David P. Greenberg, Larry K. Pickering, Shelly D. Senders, Jeffrey D. Bissey, Robert A. Howard, Mark M. Blatter, Keith Reisinger, Michael E. Pichichero, Barbara J. Howe

Research output: Contribution to journalArticlepeer-review

28 Scopus citations


Objective. Currently, 4 diphtheria-tetanus-acellular pertussis (DTaP) vaccines are licensed for pediatric use in the United States, and 2 are commercially available. Although a single manufacturer's DTaP vaccine should be used for all 3 doses of the primary immunization series, some circumstances result in infants receiving DTaP vaccines from more than 1 manufacturer. The purpose of this study was to evaluate the safety and immunogenicity of a mixed sequence of 2 different DTaP vaccines. Methods. In this multicenter, observer-blinded, controlled study, 449 infants were randomized into 1 of 3 groups (1:1:1 ratio) to receive Tripedia at 2, 4, and 6 months of age (control group); Tripedia at 2 and 4 months of age and Infanrix at 6 months of age; or Tripedia at 2 months and Infanrix at 4 and 6 months of age. Other vaccines were administered concurrently as separate injections according to the recommended childhood immunization schedule. Safety was monitored closely, and standard enzyme immunoassays were used to measure antibody concentrations to each antigen of the DTaP vaccines. Results. The rates of injection-site and systemic adverse events were similar in each study group, and there were no clinically significant differences among groups after any dose. Infants in all 3 groups responded well to each antigen contained in both vaccines, with 97% to 100% seroprotection or vaccine response rates after the 3-dose primary series. Postvaccination geometric mean antibody concentrations and seroprotection or vaccine response rates to nearly all vaccine antigens were as high or higher in the mixed-sequence groups as in the control group. Conclusion. Initiating the primary immunization series with 1 or 2 doses of Tripedia and completing the 3-dose series with Infanrix is as safe and at least as immunogenic as administering Tripedia for all 3 doses.

Original languageEnglish
Pages (from-to)666-672
Number of pages7
Issue number4
StatePublished - 17 Apr 2002
Externally publishedYes


  • Diphtheria-tetanus-pertussis vaccine
  • Immunogenicity
  • Infant
  • Interchangeability

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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