Interference of the galactose-dependent binding of lectins by novel pentapeptide ligands

Christopher J. Arnusch, Sabine André, Paola Valentini, Martin Lensch, Roland Russwurm, Hans Christian Siebert, Marcel J.E. Fischer, Hans Joachim Gabius, Roland J. Pieters

Research output: Contribution to journalArticlepeer-review

33 Scopus citations

Abstract

A library of pentapeptides containing the sequence -Y-X-Y- based on rational design was screened with six different lectins. Sequences were identified that modulate galectin binding to its natural carbohydrate ligand. SPR showed inhibition values 2-3 times stronger than galactose and NMR studies suggested real carbohydrate mimicry.

Original languageEnglish
Pages (from-to)1437-1440
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume14
Issue number6
DOIs
StatePublished - 22 Mar 2004
Externally publishedYes

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