Interferon-ε protects the female reproductive tract from viral and bacterial infection

Ka Yee Fung; Niamh E. Mangan; Helen Cumming; Jay C. Horvat; Jemma R. Mayall; Sebastian A. Stifter; Nicole De Weerd; Laila C. Roisman; Jamie Rossjohn; Sarah A. Robertson; John E. Schjenken; Belinda Parker; Caroline E. Gargett; Hong P.T. Nguyen; Daniel J. Carr; Philip M. Hansbro; Paul J. Hertzog

doi:10.1126/science.1233321

Interferon-ε protects the female reproductive tract from viral and bacterial infection

Ka Yee Fung, Niamh E. Mangan, Helen Cumming, Jay C. Horvat, Jemma R. Mayall, Sebastian A. Stifter, Nicole De Weerd, Laila C. Roisman, Jamie Rossjohn, Sarah A. Robertson, John E. Schjenken, Belinda Parker, Caroline E. Gargett, Hong P.T. Nguyen, Daniel J. Carr, Philip M. Hansbro, Paul J. Hertzog

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189 Scopus citations

Abstract

The innate immune system senses pathogens through pattern-recognition receptors (PRRs) that signal to induce effector cytokines, such as type I interferons (IFNs). We characterized IFN-ε as a type I IFN because it signaled via the Ifnar1 and Ifnar2 receptors to induce IFN-regulated genes. In contrast to other type I IFNs, IFN-e was not induced by known PRR pathways; instead, IFN-ε was constitutively expressed by epithelial cells of the female reproductive tract (FRT) and was hormonally regulated. Ifn-ε-deficient mice had increased susceptibility to infection of the FRT by the common sexually transmitted infections (STIs) herpes simplex virus 2 and Chlamydia muridarum. Thus, IFN-ε is a potent antipathogen and immunoregulatory cytokine that may be important in combating STIs that represent a major global health and socioeconomic burden.

Original language	English
Pages (from-to)	1033c
Journal	Science
Volume	339
Issue number	6123
DOIs	https://doi.org/10.1126/science.1233321
State	Published - 1 Mar 2013
Externally published	Yes

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Fung, K. Y., Mangan, N. E., Cumming, H., Horvat, J. C., Mayall, J. R., Stifter, S. A., De Weerd, N., Roisman, L. C., Rossjohn, J., Robertson, S. A., Schjenken, J. E., Parker, B., Gargett, C. E., Nguyen, H. P. T., Carr, D. J., Hansbro, P. M., & Hertzog, P. J. (2013). Interferon-ε protects the female reproductive tract from viral and bacterial infection. Science, 339(6123), 1033c. https://doi.org/10.1126/science.1233321

@article{d8b300b99e8441c098e955b535221ef8,

title = "Interferon-ε protects the female reproductive tract from viral and bacterial infection",

abstract = "The innate immune system senses pathogens through pattern-recognition receptors (PRRs) that signal to induce effector cytokines, such as type I interferons (IFNs). We characterized IFN-ε as a type I IFN because it signaled via the Ifnar1 and Ifnar2 receptors to induce IFN-regulated genes. In contrast to other type I IFNs, IFN-e was not induced by known PRR pathways; instead, IFN-ε was constitutively expressed by epithelial cells of the female reproductive tract (FRT) and was hormonally regulated. Ifn-ε-deficient mice had increased susceptibility to infection of the FRT by the common sexually transmitted infections (STIs) herpes simplex virus 2 and Chlamydia muridarum. Thus, IFN-ε is a potent antipathogen and immunoregulatory cytokine that may be important in combating STIs that represent a major global health and socioeconomic burden.",

author = "Fung, {Ka Yee} and Mangan, {Niamh E.} and Helen Cumming and Horvat, {Jay C.} and Mayall, {Jemma R.} and Stifter, {Sebastian A.} and {De Weerd}, Nicole and Roisman, {Laila C.} and Jamie Rossjohn and Robertson, {Sarah A.} and Schjenken, {John E.} and Belinda Parker and Gargett, {Caroline E.} and Nguyen, {Hong P.T.} and Carr, {Daniel J.} and Hansbro, {Philip M.} and Hertzog, {Paul J.}",

year = "2013",

month = mar,

day = "1",

doi = "10.1126/science.1233321",

language = "English",

volume = "339",

pages = "1033c",

journal = "Science",

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publisher = "American Association for the Advancement of Science",

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Fung, KY, Mangan, NE, Cumming, H, Horvat, JC, Mayall, JR, Stifter, SA, De Weerd, N, Roisman, LC, Rossjohn, J, Robertson, SA, Schjenken, JE, Parker, B, Gargett, CE, Nguyen, HPT, Carr, DJ, Hansbro, PM & Hertzog, PJ 2013, 'Interferon-ε protects the female reproductive tract from viral and bacterial infection', Science, vol. 339, no. 6123, pp. 1033c. https://doi.org/10.1126/science.1233321

TY - JOUR

T1 - Interferon-ε protects the female reproductive tract from viral and bacterial infection

AU - Fung, Ka Yee

AU - Mangan, Niamh E.

AU - Cumming, Helen

AU - Horvat, Jay C.

AU - Mayall, Jemma R.

AU - Stifter, Sebastian A.

AU - De Weerd, Nicole

AU - Roisman, Laila C.

AU - Rossjohn, Jamie

AU - Robertson, Sarah A.

AU - Schjenken, John E.

AU - Parker, Belinda

AU - Gargett, Caroline E.

AU - Nguyen, Hong P.T.

AU - Carr, Daniel J.

AU - Hansbro, Philip M.

AU - Hertzog, Paul J.

PY - 2013/3/1

Y1 - 2013/3/1

N2 - The innate immune system senses pathogens through pattern-recognition receptors (PRRs) that signal to induce effector cytokines, such as type I interferons (IFNs). We characterized IFN-ε as a type I IFN because it signaled via the Ifnar1 and Ifnar2 receptors to induce IFN-regulated genes. In contrast to other type I IFNs, IFN-e was not induced by known PRR pathways; instead, IFN-ε was constitutively expressed by epithelial cells of the female reproductive tract (FRT) and was hormonally regulated. Ifn-ε-deficient mice had increased susceptibility to infection of the FRT by the common sexually transmitted infections (STIs) herpes simplex virus 2 and Chlamydia muridarum. Thus, IFN-ε is a potent antipathogen and immunoregulatory cytokine that may be important in combating STIs that represent a major global health and socioeconomic burden.

AB - The innate immune system senses pathogens through pattern-recognition receptors (PRRs) that signal to induce effector cytokines, such as type I interferons (IFNs). We characterized IFN-ε as a type I IFN because it signaled via the Ifnar1 and Ifnar2 receptors to induce IFN-regulated genes. In contrast to other type I IFNs, IFN-e was not induced by known PRR pathways; instead, IFN-ε was constitutively expressed by epithelial cells of the female reproductive tract (FRT) and was hormonally regulated. Ifn-ε-deficient mice had increased susceptibility to infection of the FRT by the common sexually transmitted infections (STIs) herpes simplex virus 2 and Chlamydia muridarum. Thus, IFN-ε is a potent antipathogen and immunoregulatory cytokine that may be important in combating STIs that represent a major global health and socioeconomic burden.

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DO - 10.1126/science.1233321

M3 - Comment/debate

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AN - SCOPUS:84874396777

SN - 0036-8075

VL - 339

SP - 1033c

JO - Science

JF - Science

IS - 6123

ER -

Interferon-ε protects the female reproductive tract from viral and bacterial infection

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