Interferon inhibition of lymphocyte mitogenesis

Y. Weinstein, B. R. Brodeur, K. L. Melmon, T. C. Merigan

Research output: Contribution to journalArticlepeer-review

31 Scopus citations


Interferon inhibits the early phase of mitogenic action of Concanavalin A on lymphocytes as measured by incorporation of labelled precursors in RNA, DNA or protein. There was no evidence for a role of cyclic AMP in the process of inhibition. Dialysis of interferon againt high salt and urea did not separate cell inhibitory activity from antiviral activity. Thus, these results are compatible with the posssibility that the antiviral and cell inhibitory activities are in the same molecule. However, further purification of the interferon will be required to verify this assumption.

Original languageEnglish
Pages (from-to)313-319
Number of pages7
Issue number3
StatePublished - 1 Dec 1977
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


Dive into the research topics of 'Interferon inhibition of lymphocyte mitogenesis'. Together they form a unique fingerprint.

Cite this