Interleukin-1 - A major pleiotropic cytokine in tumor-host interactions

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171 Scopus citations

Abstract

Interleukin-1 (IL-1) represents a family of two agonistic proteins, IL-1α and IL-1β, that are pleiotropic and affect hemopoiesis, inflammation, and immunity. In the context of the producing cell, IL-1β is solely active in its secreted form, whereas IL-1α is active as an intracellular precursor, as a membrane-associated cytokine and to a lesser extent as a secreted molecule. IL-1 is abundant at tumor sites, where it may not only affect the growth and invasiveness of malignant cells, but where it may also induce antitumor immunity. Here we review the effects of microenvironmental and tumor cell-associated IL-1 on malignant processes, in experimental tumor models and in cancer patients.

Original languageEnglish
Pages (from-to)277-290
Number of pages14
JournalSeminars in Cancer Biology
Volume12
Issue number4
DOIs
StatePublished - 1 Jan 2002

Keywords

  • Antitumor immunity
  • Carcinognesis
  • IL-1α
  • IL-1β
  • Immunotherapy
  • Tumor invasiveness

ASJC Scopus subject areas

  • Cancer Research

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