Interleukin-1 and tumor necrosis factor-α in the Reed-Sternberg cells of Hodgkin's disease. Correlation with clinical and morphological "inflammatory" features

Daniel Benharroch

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11 Scopus citations

Abstract

We examined paraffin sections for the expression of interleukin-1α, interleukin-1β and tumor necrosis factor-α, in 40 cases of Hodgkin's disease. Our purpose was to study the role of these cytokines in the "inflammatory" histological features and "B" symptoms in this disease. Immunohistochemistry with the avidin-biotin-peroxidase complex method was used. The findings were compared with those of 20 cases of non-Hodgkin's lymphomas and of 20 non-neoplastic lymphadenopathies. Evidence for EBV infection and myc and ras oncoproteins expression was also studied in these patients, but no correlation between any of these features and cytokine expression was found. We found a significant correlation between the expression of interleukin-1β and several "inflammatory" histological features, as well as between the expression of tumor necrosis factor-α and B symptoms and tumor bulk. The differential correlations between these major pro-inflammatory cytokines expression and the "inflammatory" manifestations in Hodgkin's disease are remarkable, considering the complexity of the cytokines composing the cytokine network involved in this disease. Keywords: Interleukin-1, tumor necrosis factor-α; Hodgkin's disease.

Original languageEnglish
Pages (from-to)51-56
Number of pages6
JournalEuropean Cytokine Network
Volume7
Issue number1
StatePublished - 1 Dec 1996

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