Interleukin- 12 receptor β1 deficiency presenting as recurrent Salmonella infection

Orna Staretz-Haham, Rimma Melamed, Matitiahu Lifshitz, Nurith Porat, Claire Fieschi, Jean Laurent Casanova, Jacov Levy

Research output: Contribution to journalArticlepeer-review

37 Scopus citations


We describe a child with interleukin-12 receptor β1 (IL-12Rβ1) deficiency caused by a homozygous IL12RB1 large deletion who presented at the age of 1 year with recurrent, often asymptomatic episodes of bacteremia caused by group D Salmonella species. No mycobacterial disease or other unusual infection was present. The episodes of salmonellosis were caused by an identical serovar during a period of 18 months. This is the first case of inherited IL-12Rβ1 deficiency diagnosed after isolated, recurrent salmonellosis.

Original languageEnglish
Pages (from-to)137-140
Number of pages4
JournalClinical Infectious Diseases
Issue number1
StatePublished - 1 Jul 2003

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases


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