Internal dynamics of superhelical DNA

Roman Shusterman, Tatyana Gavrinyov, Oleg Krichevsky

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

We present the first data on the temporal kinetics of monomer mean square displacements in DNA circles with defined degrees of superhelicity. The segmental dynamics of specifically labeled DNA plasmids with superhelical densities between 0 and -0.016 was assessed by fluorescence correlation spectroscopy. Introduction of superhelicity leads to progressively faster dynamics in the long time regime corresponding to the coil diffusion as observed previously by Langowski et al., but also in the short time range corresponding to the segmental motion within the DNA coil.

Original languageEnglish
Article number098102
JournalPhysical Review Letters
Volume100
Issue number9
DOIs
StatePublished - 6 Mar 2008

ASJC Scopus subject areas

  • Physics and Astronomy (all)

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