Interplay of noncovalent interactions in antiseptic quaternary ammonium surfactant Miramistin

Fedor M. Dolgushin, Alexander S. Goloveshkin, Ivan V. Ananyev, Svetlana V. Osintseva, Yury V. Torubaev, Sergey S. Krylov, Alexandre S. Golub

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


The molecular and crystal structure of the widely used antiseptic benzyldimethyl{3-[(1-oxotetradecyl)amino]propyl}ammonium chloride monohydrate (Miramistin, MR), C 26 H 47 N 2 O + ·Cl ·H 2 O, was determined by a single-crystal X-ray diffraction study and analyzed in the framework of the QTAIM (quantum theory of atoms in molecules) approach using both periodic and molecular DFT (density functional theory) calculations. The various noncovalent intermolecular interactions of different strengths were found to be realized in the hydrophilic parts of the crystal packing (i.e. O—H…Cl, N—H…Cl, C—H…Cl, C—H…O and C—H…π). The hydrophobic parts are built up exclusively by van der Waals H…H contacts. Quantification of the interaction energies using calculated electron-density distribution revealed that the total energy of the contacts within the hydrophilic and hydrophobic regions are comparable in value. The organic MR cation adopts the bent conformation with the head group tilted back to the long-chain alkyl tail in both the crystalline and the isolated state due to stabilization of this geometry by several intramolecular C—H…π, C—H…N and H…H interactions. This conformation preference is hypothesized to play an important role in the interaction of MR with biomembranes.

Original languageEnglish
Pages (from-to)402-411
Number of pages10
JournalActa crystallographica. Section C, Structural chemistry
Issue number4
StatePublished - 1 Apr 2019
Externally publishedYes


  • amphiphilic molecule
  • antiseptic
  • crystal structure
  • hydrogen bonding
  • hydrophobic interaction
  • periodic DFT calculation
  • quaternary ammonium surfactant

ASJC Scopus subject areas

  • Condensed Matter Physics
  • Physical and Theoretical Chemistry
  • Inorganic Chemistry
  • Materials Chemistry


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