Intracellular IL-1 alpha in fibroblasts as a possible endogenous mediator of joint damage in rheumatoid arthritis

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Abstract

Interleukin-1 (IL-1) and tumor necrosis factor α (TNFα) are the most potent pro-inflammatory cytokines. Acting in synergy, they mediate many consequences of inflammatory responses. IL-1 consists of a family of two proteins, namely IL-1α and IL-1β. It is shown that fibroblasts display a unique pattern of IL-1 expression. Under inflammatory conditions, fibroblasts display inductive patterns of IL-1α bioactivity.

Original languageEnglish
Pages (from-to)285-288
Number of pages4
JournalIsrael Journal of Medical Sciences
Volume33
Issue number4
StatePublished - 1 Apr 1997

Keywords

  • Fibroblasts
  • Rheumatoid arthritis

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