Intracellular zinc inhibits KCC2 transporter activity

Michal Hershfinkel, Karl Kandler, Megan E. Knoch, Michal Dagan-Rabin, Mandar A. Aras, Chen Abramovitch-Dahan, Israel Sekler, Elias Aizenman

Research output: Contribution to journalArticlepeer-review

53 Scopus citations


We found that K+/Cl- co-transporter 2 (KCC2) activity, monitored with wide-field fluorescence, was inhibited by intracellular Zn 2+, a major component of neuronal injury. Zn2+- mediated KCC2 inhibition produced a depolarizing shift of GABA A reversal potentials in rat cortical neurons. Moreover, oxygen-glucose deprivation attenuated KCC2 activity in a Zn2+-dependent manner. The link between Zn2+and KCC2 activity provides a previously unknown target for neuroprotection and may be important in activity-dependent regulation of inhibitory synaptic transmission.

Original languageEnglish
Pages (from-to)725-727
Number of pages3
JournalNature Neuroscience
Issue number6
StatePublished - 1 Jun 2009

ASJC Scopus subject areas

  • Neuroscience (all)


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