@article{f21c56c19dfc430f84a2b7ce305c9c8b,
title = "Intracerebroventricular myo-inositol antagonizes lithium-induced suppression of rearing behaviour in rats",
abstract = "Several biological effects of lithium have been reversed by in vitro myo-inositol. To determine if intracerebroventricular myo-inositol would reverse behavioural effects of lithium, rats were injected with 5 meq/kg lithium choloride or sodium chloride and injected intracranially with myo-inositol (10 mg) or artificial CSF 24 h and 15 min prior to measurement of activity in an automated activity monitor. Myo-inositol alone had no significant effect on behaviour, but significantly reversed suppression of rearing activity by lithium.",
keywords = "Intracerebroventricular, Lithium, Locomotor activity, Myo-inositol",
author = "Ora Kofman and Belmaker, \{R. H.\}",
note = "Funding Information: 1 Allison, J.H., Boshans, R.L., Hallcher, L.M., Packman, P.M. and Sherman, W.R,, The effects of lithium on myo-inositol levels in layers of frontal cerebral cortex, in cerebellum, and in corpus eallosum in rats, J. Neurochem., 34 (1980) 456--458. 2 Allison, J.H., Blisner, M.E., Holland, W.H., Hipps, P.P. and Sherman, W.R., Increased brain myo-inositoi 1-phosphate in lithium-treated rats, Biochem. Biophys. Res. Commun., 71 (1976) 664-670. 3 Avissar, S., Schreiber, G., Danon, A. and Belmaker, R.H., Lithium inhibits adrenergic and cholinergic increases in GTP binding in rat cortex, Nature, 331 (1988) 440-442. 4 Belmaker, R.H., Livne, A., Moscovitch, D.G., Grisaru, N., Schreiber, G., Avissar, S., Danon, A. and Kofman, O., Role of inositol-l-phosphatase inhibition in the mechanism of action of lithium, Pharmacol. Toxicol., 66, Suppl. III (1990) 76-83. 5 Belmaker, R.H., Zohar, J., Ebstein, R.P., Cyclic nucleotides in mental disorder. In P. Hamet and H. Sands (Eds.), Advances in Cyclic Nucleotide Research, Vol. 12, Raven, New York, 1980, pp. 187-198. 6 Berggren, U., Effects of chronic lithium treatment on brain monoamine metabolism and amphetamine-induced locomotor stimulation in rats, J. Neural Transm., 64 (1985) 239-250. 7 Berridge, M.J., Downes, C.P. and Haniey, M.R., Lithium amplifies agonist-dependent phosphatidylinositol responses in brain and salivary glands, Biochem. J., 206 (1982) 587-595. 8 Busa, W.B. and Gimlich, R.L., Lithium-induced teratogenesis in frog embroys prevented by a polyphosphoinositide cycle inter-mediate or a diacylglycerol analog, Dev. Biol., 132 (1989) 315-324. 9 Casebolt, T.L. and Jope, R.S., Long-term lithium treatment selectively reduces receptor-coupled inositol phopholipid hy-drolysis in rat brain, Biol. Psychiat., 25 (1989) 329-340. 10 Davies, C., Sanger, D.J., Steinberg, H., Tomkiewicz, M. and U'Priehard, D.C., Lithium and alpha-methyl-p-tyrosine prevent 'manic' activity in rodents, Psychopharmacology, 36 (1974) 263-274. 11 Downes, C.P. and Stone, M.A., Lithium-induced reduction in intracellular inositol supply in cholinergically stimulated parotid gland, Biochem. J., 234 (1986) 199-204. 12 Furakawa, T., Ushijima, I. and Ono, N., Modification by lithium of behavioral responses to methamphetamine and tetrabenazine, Psychopharmacologia, 42 (1975) 243-248. 13 Godfrey, P.P., Potentiation by lithium of CMP-phosphatidate formation in carbochol-stimulated rat cerebral-cortical slices and its reversal by myo-inositol, Biochem. J., 258 (1989) 621-624. 14 Honchar, M.P., Ackerman, K.E. and Sherman, W.R., Chron-ically administered lithium alters neither myo-inositol mono-phosphatase activity nor phosphoinositide levels in rat brain, J. Neurochem., 53 (1989) 590-594. 15 Johnson, EN., Dissociation of vertical and horizontal compo- Supported by grants from the Israel Psychobiology Foundation and the Israel Ministry of Absorption (O.K.) and the Harry Stern Foundation (R.H.B.). The technical assistance of Chava Alpert, Iris Fuchs, Oren Rigler and Hady Shimon is gratefully acknowledged.",
year = "1990",
month = nov,
day = "26",
doi = "10.1016/0006-8993(90)90155-5",
language = "English",
volume = "534",
pages = "345--347",
journal = "Brain Research",
issn = "0006-8993",
publisher = "Elsevier B.V.",
number = "1-2",
}