Intramolecular copper(I)-catalyzed 1,3-dipolar cycloaddition of azido-alkynes: Synthesis of triazolo-benzoxazepine derivatives and their biological evaluation

Srivari Chandrasekhar, Mallikanti Seenaiah, Abhishek Kumar, Chada Raji Reddy, Suman Kumar Mamidyala, Chityal Ganesh Kumar, Sridhar Balasubramanian

Research output: Contribution to journalArticlepeer-review

47 Scopus citations

Abstract

Synthesis of a series of [1,2,3] triazolo [5,1-c] [1,4]benzoxazepine derivatives have been accomplished by the intramolecular Cu(I)-catalyzed cycloaddition of azido-alkynes derived from salicylaldehyde. The biological profile of these heterocyclic structural scaffolds toward anti-bacterial as well as anti-fungal activity has also been illustrated.

Original languageEnglish
Pages (from-to)806-808
Number of pages3
JournalTetrahedron Letters
Volume52
Issue number7
DOIs
StatePublished - 16 Feb 2011
Externally publishedYes

Keywords

  • 1,3-Dipolar cycloaddition
  • Anti-microbial
  • Click chemistry
  • Copper-catalysis
  • Triazolo-benzoxazepine

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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