Intraplacental choriocarcinoma metastasizing to the maternal lung

D. Landau, E. Maor, E. Maymon, A. Rabinovich, B. Piura

    Research output: Contribution to journalArticlepeer-review

    12 Scopus citations


    Background: Although normal pregnancy is the precursor of 25% of cases of maternal choriocarcinoma, intraplacental choriocarcinoma in an otherwise normal placenta associated with viable pregnancy has rarely been reported. Case: Examination of the placenta after delivery of a pale and small-for-date infant at term revealed intraplacental choriocarcinoma. There was no evidence of metastatic disease in the mother or child, but the mother exhibited postpartum rising levels of beta-HCG. The mother refused chemotherapy and disappeared from follow-up. Nine months later, she presented with metastatic choriocarcinoma of the lung. Eleven courses of the multi-drug EMA CO regimen effected a decrease of beta-HCG to normal and disappearance of lung metastases. To date, 28 months after the end of chemotherapy, the patient is alive and without evidence of gestational trophoblastic disease. Moreover, since then she has given birth to an additional two children. Conclusions: This case is an example of natural disease progression of intraplacental choriocarcinoma metastasizing to the mother. Furthermore, it supports common knowledge that the multi-drug EMA CO regimen is effective treatment in poor prognosis metastatic choriocarcinoma.

    Original languageEnglish
    Pages (from-to)29-32
    Number of pages4
    JournalEuropean Journal of Gynaecological Oncology
    Issue number1
    StatePublished - 23 Mar 2006


    • Chemotherapy
    • Choriocarcinoma
    • EMA CO regimen
    • Placenta
    • Trophoblast

    ASJC Scopus subject areas

    • Oncology
    • Obstetrics and Gynecology


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