Intrastriatal transplantation of mouse bone marrow-derived stem cells improves motor behavior in a mouse model of Parkinson's disease

D. Offen, Y. Barhum, Y. S. Levy, A. Burshtein, H. Panet, T. Cherlow, E. Melamed

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

55 Scopus citations


Strategies of cell therapy for the treatment of Parkinson's disease (PD) are focused on replacing damaged neurons with cells to restore or improve function that is impaired due to cell population damage. In our studies, we used mesenchymal stromal cells (MSCs) from mouse bone marrow. Following our novel neuronal differentiation method, we found that the basic cellular phenotype changed to cells with neural morphology that express specific markers including those characteristic for dopaminergic neurons, such as tyrosine hydroxylase (TH). Intrastriatal transplantation of the differentiated MSCs in 6-hydroxydopamine-lesioned mice led to marked reduction in the amphetamine-induced rotations. Immunohistological analysis of the mice brains four months post transplantation, demonstrated that most of the transplanted cells survived in the striatum and expressed TH. Some of the TH positive cells migrated toward the substantia nigra. In conclusion, transplantation of bone marrow derived stem cells differentiated to dopaminergic-like cells, successfully improved behavior in an animal model of PD suggesting an accessible source of cells that may be used for autotransplantation in patient with PD.

Original languageEnglish
Title of host publicationNeuropsychiatric Disorders An Integrative Approach
PublisherSpringer Wien
Number of pages11
ISBN (Print)9783211735732
StatePublished - 1 Jan 2007
Externally publishedYes

Publication series

NameJournal of Neural Transmission, Supplementa
ISSN (Print)0303-6995


  • Multipotent mesenchymal stromal cells (MSCs)
  • Parkinson's disease (PD)
  • dopamine
  • dopaminergic neurons
  • stem cells

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health
  • Biological Psychiatry


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