Intrauterine infection/inflammation during pregnancy and offspring brain damages: Possible mechanisms involved

Mahmoud Huleihel, Hava Golan, Mordechai Hallak

Research output: Contribution to journalReview articlepeer-review

72 Scopus citations

Abstract

Intrauterine infection is considered as one of the major maternal insults during pregnancy. Intrauterine infection during pregnancy could lead to brain damage of the developmental fetus and offspring. Effects on the fetal, newborn, and adult central nervous system (CNS) may include signs of neurological problems, developmental abnormalities and delays, and intellectual deficits. However, the mechanisms or pathophysiology that leads to permanent brain damage during development are complex and not fully understood. This damage may affect morphogenic and behavioral phenotypes of the developed offspring, and that mice brain damage could be mediated through a final common pathway, which includes over-stimulation of excitatory amino acid receptor, over-production of vascularization/angiogenesis, pro-inflammatory cytokines, neurotrophic factors and apoptotic-inducing factors.

Original languageEnglish
Article number17
JournalReproductive Biology and Endocrinology
Volume2
DOIs
StatePublished - 22 Apr 2004

ASJC Scopus subject areas

  • Reproductive Medicine
  • Endocrinology
  • Obstetrics and Gynecology
  • Developmental Biology

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