Intravenous fosphenytoin in acute mania

Julia Applebaum, Joseph Levine, R. H. Belmaker

    Research output: Contribution to journalArticlepeer-review

    15 Scopus citations


    Objectives: Since several anticonvulsants are therapeutic in mania and since acute mania requires rapid and intensive treatment, we hypothesized that intravenous high-dose phenytoin might be acutely antimanic. A new prodrug of phenytoin, fosphenytoin, which has few cardiac or local vein side effects, was used to test this hypothesis. Method: Seven patients with a DSM-IV manic episode and minimal prior drug treatment were given intravenous fosphenytoin and were assessed at baseline and after 15, 30, 45, and 60 minutes with the Young Mania Rating Scale, the Clinical Global Impressions scale, and the Mini-3Mental State Examination. Data were gathered in 2002. Results: No antimanic effects were observed. No subject had any clear improvement in manic symptoms on the YMRS at any timepoint assessed. Conclusion: Intravenous fosphenytoin at doses that are effective in status epilepticus appears to be ineffective in acute mania.

    Original languageEnglish
    Pages (from-to)408-409
    Number of pages2
    JournalJournal of Clinical Psychiatry
    Issue number4
    StatePublished - 1 Apr 2003

    ASJC Scopus subject areas

    • Psychiatry and Mental health


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