Intraventricular Interferon Treatment for Subacute Sclerosing Panencephalitis

I. Steiner; I. Wirguin; A. Morag; O. Abramsky; Paul R. Dyken

doi:10.1177/088307388900400103

Intraventricular Interferon Treatment for Subacute Sclerosing Panencephalitis

I. Steiner, I. Wirguin, A. Morag, O. Abramsky, Paul R. Dyken

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

Three children with subacute sclerosing panencephalitis (SSPE) were treated with alpha-interferon. Medication was administered via an Ommaya reservoir into the cerebral ventricular system over a period of 13 to 24 months in increasing amounts up to 1.0 X 106 IU twice weekly. Mild clinical improvement in two children and a stable course in the third were associated with improvement of electroencephalographic recordings in all patients and a decrease in antimeasles antibodies in the cerebrospinal fluid of two. The small number of patients does not enable us to determine whether this course was the natural history of SSPE in our patients or whether it was induced by treatment, yet it seems that intraventricular interferon treatment can modify the course of SSPE. ( J Child Neurol 1989;4:20-23).

Original language	English
Pages (from-to)	20-24
Number of pages	5
Journal	Journal of Child Neurology
Volume	4
Issue number	1
DOIs	https://doi.org/10.1177/088307388900400103
State	Published - 1 Jan 1989
Externally published	Yes

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Clinical Neurology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1177/088307388900400103

Cite this

@article{3ad25a814ca840ddb2b41da2da07e845,

title = "Intraventricular Interferon Treatment for Subacute Sclerosing Panencephalitis",

abstract = "Three children with subacute sclerosing panencephalitis (SSPE) were treated with alpha-interferon. Medication was administered via an Ommaya reservoir into the cerebral ventricular system over a period of 13 to 24 months in increasing amounts up to 1.0 X 106 IU twice weekly. Mild clinical improvement in two children and a stable course in the third were associated with improvement of electroencephalographic recordings in all patients and a decrease in antimeasles antibodies in the cerebrospinal fluid of two. The small number of patients does not enable us to determine whether this course was the natural history of SSPE in our patients or whether it was induced by treatment, yet it seems that intraventricular interferon treatment can modify the course of SSPE. ( J Child Neurol 1989;4:20-23).",

author = "I. Steiner and I. Wirguin and A. Morag and O. Abramsky and Dyken, {Paul R.}",

year = "1989",

month = jan,

day = "1",

doi = "10.1177/088307388900400103",

language = "English",

volume = "4",

pages = "20--24",

journal = "Journal of Child Neurology",

issn = "0883-0738",

publisher = "SAGE Publications Inc.",

number = "1",

}

TY - JOUR

T1 - Intraventricular Interferon Treatment for Subacute Sclerosing Panencephalitis

AU - Steiner, I.

AU - Wirguin, I.

AU - Morag, A.

AU - Abramsky, O.

AU - Dyken, Paul R.

PY - 1989/1/1

Y1 - 1989/1/1

N2 - Three children with subacute sclerosing panencephalitis (SSPE) were treated with alpha-interferon. Medication was administered via an Ommaya reservoir into the cerebral ventricular system over a period of 13 to 24 months in increasing amounts up to 1.0 X 106 IU twice weekly. Mild clinical improvement in two children and a stable course in the third were associated with improvement of electroencephalographic recordings in all patients and a decrease in antimeasles antibodies in the cerebrospinal fluid of two. The small number of patients does not enable us to determine whether this course was the natural history of SSPE in our patients or whether it was induced by treatment, yet it seems that intraventricular interferon treatment can modify the course of SSPE. ( J Child Neurol 1989;4:20-23).

AB - Three children with subacute sclerosing panencephalitis (SSPE) were treated with alpha-interferon. Medication was administered via an Ommaya reservoir into the cerebral ventricular system over a period of 13 to 24 months in increasing amounts up to 1.0 X 106 IU twice weekly. Mild clinical improvement in two children and a stable course in the third were associated with improvement of electroencephalographic recordings in all patients and a decrease in antimeasles antibodies in the cerebrospinal fluid of two. The small number of patients does not enable us to determine whether this course was the natural history of SSPE in our patients or whether it was induced by treatment, yet it seems that intraventricular interferon treatment can modify the course of SSPE. ( J Child Neurol 1989;4:20-23).

UR - http://www.scopus.com/inward/record.url?scp=0024590552&partnerID=8YFLogxK

U2 - 10.1177/088307388900400103

DO - 10.1177/088307388900400103

M3 - Article

C2 - 2918207

AN - SCOPUS:0024590552

SN - 0883-0738

VL - 4

SP - 20

EP - 24

JO - Journal of Child Neurology

JF - Journal of Child Neurology

IS - 1

ER -

Intraventricular Interferon Treatment for Subacute Sclerosing Panencephalitis

Abstract

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this