Invasive Haemophilus influenzae disease, Europe, 1996-2006

Shamez Ladhani; Mary P.E. Slack; Paul T. Heath; Anne Von Gottberg; Manosree Chandra; Mary E. Ramsay; Peter McIntyre; Lyn Gilbert; Geoff Hogg; Reinhild Strauss; Sigrid Heuberger; Germaine Hanquet; Francoise Crokaert; Pavla Krizova; Vera Lebedova; Kåre Mølbak; Jens Jørgen Christensen; Kuulo Kutsar; Unna Joks; Elja Herva; Tarja Kaijalainen; Maija Leinonen; Petri Ruutu; Agnes Lepoutre; Henri Dabernat; Anette Siedler; Heinz J. Schmitt; Marie Theodoridou; Anastasia Pangalis; Georgina Tzanakaki; Miklos Fuzi; Katalin Krisztalovics; Thorolfur Gudnason; Hjordis Hardardottir; Mary Cafferkey; Suzanne Cotter; Darina O'Flanagan; Ron Dagan; Marina Cerquetti; Marta Ciofi Degli Atti; Irina Lucenko; Grazina Rimseliene; Snieguole Dauksiene; Pierette Huberty-Krau; Francois Schneider; Jackie Maistre Melillo; Sabine De Greeff; Hester De Melker; Lodewijk Spanjaard; Hans Blystad; E. Arne Hoiby; Øistein Løvoll; Andrzej Zielinski; Waleria Hryniewicz; Anna Skoczynska; Marcin Kadlubowski; Laurinda Queirós; Paula Lavado; Claire Cameron; Barbara Denham; Fiona Johnston; Margareta Slacikova; Elena Novakova; Alenka Kraigher; Metka Paragi; Jose Campos; Javier Diez-Domingo; Rose Marie Carlsson; Birgitta Henriques Normark; Hans Peter Zimmermann

doi:10.3201/eid1603.090290

Invasive Haemophilus influenzae disease, Europe, 1996-2006

Shamez Ladhani, Mary P.E. Slack, Paul T. Heath, Anne Von Gottberg, Manosree Chandra, Mary E. Ramsay, Peter McIntyre, Lyn Gilbert, Geoff Hogg, Reinhild Strauss, Sigrid Heuberger, Germaine Hanquet, Francoise Crokaert, Pavla Krizova, Vera Lebedova, Kåre Mølbak, Jens Jørgen Christensen, Kuulo Kutsar, Unna Joks, Elja HervaTarja Kaijalainen, Maija Leinonen, Petri Ruutu, Agnes Lepoutre, Henri Dabernat, Anette Siedler, Heinz J. Schmitt, Marie Theodoridou, Anastasia Pangalis, Georgina Tzanakaki, Miklos Fuzi, Katalin Krisztalovics, Thorolfur Gudnason, Hjordis Hardardottir, Mary Cafferkey, Suzanne Cotter, Darina O'Flanagan, Ron Dagan, Marina Cerquetti, Marta Ciofi Degli Atti, Irina Lucenko, Grazina Rimseliene, Snieguole Dauksiene, Pierette Huberty-Krau, Francois Schneider, Jackie Maistre Melillo, Sabine De Greeff, Hester De Melker, Lodewijk Spanjaard, Hans Blystad, E. Arne Hoiby, Øistein Løvoll, Andrzej Zielinski, Waleria Hryniewicz, Anna Skoczynska, Marcin Kadlubowski, Laurinda Queirós, Paula Lavado, Claire Cameron, Barbara Denham, Fiona Johnston, Margareta Slacikova, Elena Novakova, Alenka Kraigher, Metka Paragi, Jose Campos, Javier Diez-Domingo, Rose Marie Carlsson, Birgitta Henriques Normark, Hans Peter Zimmermann

The Shraga Segal Department of Microbiology and Immunology

Research output: Contribution to journal › Article › peer-review

188 Scopus citations

Abstract

An international collaboration was established in 1996 to monitor the impact of routine Haemophilus influenzae type b (Hib) vaccination on invasive H. influenzae disease; 14 countries routinely serotype all clinical isolates. Of the 10,081 invasive H. influenzae infections reported during 1996-2006, 4,466 (44%, incidence 0.28 infections/100,000 population) were due to noncapsulated H. influenzae (ncHi); 2,836 (28%, 0.15/100,000), to Hib; and 690 (7%, 0.036/100,000), to non-b encapsulated H. influenzae. Invasive ncHi infections occurred in older persons more often than Hib (median age 58 years vs. 5 years, p<0.0001) and were associated with higher case-fatality ratios (12% vs. 4%, p<0.0001), particularly in infants (17% vs. 3%, p<0.0001). Among non-b encapsulated H. influenzae, types f (72%) and e (21%) were responsible for almost all cases; the overall case-fatality rate was 9%. Thus, the incidence of invasive non-type b H. influenzae is now higher than that of Hib and is associated with higher case fatality.

Original language	English
Pages (from-to)	455-463
Number of pages	9
Journal	Emerging Infectious Diseases
Volume	16
Issue number	3
DOIs	https://doi.org/10.3201/eid1603.090290
State	Published - 1 Mar 2010

ASJC Scopus subject areas

Epidemiology
Microbiology (medical)
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3201/eid1603.090290

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Ladhani, S., Slack, M. P. E., Heath, P. T., Von Gottberg, A., Chandra, M., Ramsay, M. E., McIntyre, P., Gilbert, L., Hogg, G., Strauss, R., Heuberger, S., Hanquet, G., Crokaert, F., Krizova, P., Lebedova, V., Mølbak, K., Christensen, J. J., Kutsar, K., Joks, U., ... Zimmermann, H. P. (2010). Invasive Haemophilus influenzae disease, Europe, 1996-2006. Emerging Infectious Diseases, 16(3), 455-463. https://doi.org/10.3201/eid1603.090290

@article{9230f34a7e3c4b9597c3239fdcf5762c,

title = "Invasive Haemophilus influenzae disease, Europe, 1996-2006",

abstract = "An international collaboration was established in 1996 to monitor the impact of routine Haemophilus influenzae type b (Hib) vaccination on invasive H. influenzae disease; 14 countries routinely serotype all clinical isolates. Of the 10,081 invasive H. influenzae infections reported during 1996-2006, 4,466 (44%, incidence 0.28 infections/100,000 population) were due to noncapsulated H. influenzae (ncHi); 2,836 (28%, 0.15/100,000), to Hib; and 690 (7%, 0.036/100,000), to non-b encapsulated H. influenzae. Invasive ncHi infections occurred in older persons more often than Hib (median age 58 years vs. 5 years, p<0.0001) and were associated with higher case-fatality ratios (12% vs. 4%, p<0.0001), particularly in infants (17% vs. 3%, p<0.0001). Among non-b encapsulated H. influenzae, types f (72%) and e (21%) were responsible for almost all cases; the overall case-fatality rate was 9%. Thus, the incidence of invasive non-type b H. influenzae is now higher than that of Hib and is associated with higher case fatality.",

author = "Shamez Ladhani and Slack, {Mary P.E.} and Heath, {Paul T.} and {Von Gottberg}, Anne and Manosree Chandra and Ramsay, {Mary E.} and Peter McIntyre and Lyn Gilbert and Geoff Hogg and Reinhild Strauss and Sigrid Heuberger and Germaine Hanquet and Francoise Crokaert and Pavla Krizova and Vera Lebedova and K{\aa}re M{\o}lbak and Christensen, {Jens J{\o}rgen} and Kuulo Kutsar and Unna Joks and Elja Herva and Tarja Kaijalainen and Maija Leinonen and Petri Ruutu and Agnes Lepoutre and Henri Dabernat and Anette Siedler and Schmitt, {Heinz J.} and Marie Theodoridou and Anastasia Pangalis and Georgina Tzanakaki and Miklos Fuzi and Katalin Krisztalovics and Thorolfur Gudnason and Hjordis Hardardottir and Mary Cafferkey and Suzanne Cotter and Darina O'Flanagan and Ron Dagan and Marina Cerquetti and {Ciofi Degli Atti}, Marta and Irina Lucenko and Grazina Rimseliene and Snieguole Dauksiene and Pierette Huberty-Krau and Francois Schneider and Melillo, {Jackie Maistre} and {De Greeff}, Sabine and {De Melker}, Hester and Lodewijk Spanjaard and Hans Blystad and Hoiby, {E. Arne} and {\O}istein L{\o}voll and Andrzej Zielinski and Waleria Hryniewicz and Anna Skoczynska and Marcin Kadlubowski and Laurinda Queir{\'o}s and Paula Lavado and Claire Cameron and Barbara Denham and Fiona Johnston and Margareta Slacikova and Elena Novakova and Alenka Kraigher and Metka Paragi and Jose Campos and Javier Diez-Domingo and Carlsson, {Rose Marie} and Normark, {Birgitta Henriques} and Zimmermann, {Hans Peter}",

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Ladhani, S, Slack, MPE, Heath, PT, Von Gottberg, A, Chandra, M, Ramsay, ME, McIntyre, P, Gilbert, L, Hogg, G, Strauss, R, Heuberger, S, Hanquet, G, Crokaert, F, Krizova, P, Lebedova, V, Mølbak, K, Christensen, JJ, Kutsar, K, Joks, U, Herva, E, Kaijalainen, T, Leinonen, M, Ruutu, P, Lepoutre, A, Dabernat, H, Siedler, A, Schmitt, HJ, Theodoridou, M, Pangalis, A, Tzanakaki, G, Fuzi, M, Krisztalovics, K, Gudnason, T, Hardardottir, H, Cafferkey, M, Cotter, S, O'Flanagan, D, Dagan, R, Cerquetti, M, Ciofi Degli Atti, M, Lucenko, I, Rimseliene, G, Dauksiene, S, Huberty-Krau, P, Schneider, F, Melillo, JM, De Greeff, S, De Melker, H, Spanjaard, L, Blystad, H, Hoiby, EA, Løvoll, Ø, Zielinski, A, Hryniewicz, W, Skoczynska, A, Kadlubowski, M, Queirós, L, Lavado, P, Cameron, C, Denham, B, Johnston, F, Slacikova, M, Novakova, E, Kraigher, A, Paragi, M, Campos, J, Diez-Domingo, J, Carlsson, RM, Normark, BH & Zimmermann, HP 2010, 'Invasive Haemophilus influenzae disease, Europe, 1996-2006', Emerging Infectious Diseases, vol. 16, no. 3, pp. 455-463. https://doi.org/10.3201/eid1603.090290

TY - JOUR

T1 - Invasive Haemophilus influenzae disease, Europe, 1996-2006

AU - Ladhani, Shamez

AU - Slack, Mary P.E.

AU - Heath, Paul T.

AU - Von Gottberg, Anne

AU - Chandra, Manosree

AU - Ramsay, Mary E.

AU - McIntyre, Peter

AU - Gilbert, Lyn

AU - Hogg, Geoff

AU - Strauss, Reinhild

AU - Heuberger, Sigrid

AU - Hanquet, Germaine

AU - Crokaert, Francoise

AU - Krizova, Pavla

AU - Lebedova, Vera

AU - Mølbak, Kåre

AU - Christensen, Jens Jørgen

AU - Kutsar, Kuulo

AU - Joks, Unna

AU - Herva, Elja

AU - Kaijalainen, Tarja

AU - Leinonen, Maija

AU - Ruutu, Petri

AU - Lepoutre, Agnes

AU - Dabernat, Henri

AU - Siedler, Anette

AU - Schmitt, Heinz J.

AU - Theodoridou, Marie

AU - Pangalis, Anastasia

AU - Tzanakaki, Georgina

AU - Fuzi, Miklos

AU - Krisztalovics, Katalin

AU - Gudnason, Thorolfur

AU - Hardardottir, Hjordis

AU - Cafferkey, Mary

AU - Cotter, Suzanne

AU - O'Flanagan, Darina

AU - Dagan, Ron

AU - Cerquetti, Marina

AU - Ciofi Degli Atti, Marta

AU - Lucenko, Irina

AU - Rimseliene, Grazina

AU - Dauksiene, Snieguole

AU - Huberty-Krau, Pierette

AU - Schneider, Francois

AU - Melillo, Jackie Maistre

AU - De Greeff, Sabine

AU - De Melker, Hester

AU - Spanjaard, Lodewijk

AU - Blystad, Hans

AU - Hoiby, E. Arne

AU - Løvoll, Øistein

AU - Zielinski, Andrzej

AU - Hryniewicz, Waleria

AU - Skoczynska, Anna

AU - Kadlubowski, Marcin

AU - Queirós, Laurinda

AU - Lavado, Paula

AU - Cameron, Claire

AU - Denham, Barbara

AU - Johnston, Fiona

AU - Slacikova, Margareta

AU - Novakova, Elena

AU - Kraigher, Alenka

AU - Paragi, Metka

AU - Campos, Jose

AU - Diez-Domingo, Javier

AU - Carlsson, Rose Marie

AU - Normark, Birgitta Henriques

AU - Zimmermann, Hans Peter

PY - 2010/3/1

Y1 - 2010/3/1

N2 - An international collaboration was established in 1996 to monitor the impact of routine Haemophilus influenzae type b (Hib) vaccination on invasive H. influenzae disease; 14 countries routinely serotype all clinical isolates. Of the 10,081 invasive H. influenzae infections reported during 1996-2006, 4,466 (44%, incidence 0.28 infections/100,000 population) were due to noncapsulated H. influenzae (ncHi); 2,836 (28%, 0.15/100,000), to Hib; and 690 (7%, 0.036/100,000), to non-b encapsulated H. influenzae. Invasive ncHi infections occurred in older persons more often than Hib (median age 58 years vs. 5 years, p<0.0001) and were associated with higher case-fatality ratios (12% vs. 4%, p<0.0001), particularly in infants (17% vs. 3%, p<0.0001). Among non-b encapsulated H. influenzae, types f (72%) and e (21%) were responsible for almost all cases; the overall case-fatality rate was 9%. Thus, the incidence of invasive non-type b H. influenzae is now higher than that of Hib and is associated with higher case fatality.

AB - An international collaboration was established in 1996 to monitor the impact of routine Haemophilus influenzae type b (Hib) vaccination on invasive H. influenzae disease; 14 countries routinely serotype all clinical isolates. Of the 10,081 invasive H. influenzae infections reported during 1996-2006, 4,466 (44%, incidence 0.28 infections/100,000 population) were due to noncapsulated H. influenzae (ncHi); 2,836 (28%, 0.15/100,000), to Hib; and 690 (7%, 0.036/100,000), to non-b encapsulated H. influenzae. Invasive ncHi infections occurred in older persons more often than Hib (median age 58 years vs. 5 years, p<0.0001) and were associated with higher case-fatality ratios (12% vs. 4%, p<0.0001), particularly in infants (17% vs. 3%, p<0.0001). Among non-b encapsulated H. influenzae, types f (72%) and e (21%) were responsible for almost all cases; the overall case-fatality rate was 9%. Thus, the incidence of invasive non-type b H. influenzae is now higher than that of Hib and is associated with higher case fatality.

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U2 - 10.3201/eid1603.090290

DO - 10.3201/eid1603.090290

M3 - Article

C2 - 20202421

AN - SCOPUS:77649108075

SN - 1080-6040

VL - 16

SP - 455

EP - 463

JO - Emerging Infectious Diseases

JF - Emerging Infectious Diseases

IS - 3

ER -

Invasive Haemophilus influenzae disease, Europe, 1996-2006

Abstract

ASJC Scopus subject areas

UN SDGs

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