TY - JOUR
T1 - Invasive Multidrug-Resistant emm93.0 Streptococcus pyogenes Strain Harboring a Novel Genomic Island, Israel, 2017-2019
AU - Ron, Merav
AU - Brosh-Nissimov, Tal
AU - Korenman, Zinaida
AU - Treygerman, Orit
AU - Sagi, Orli
AU - Valinsky, Lea
AU - Rokney, Assaf
N1 - Funding Information:
The laboratory work of this study was performed at the Public Health Laboratory, Jerusalem, Israel, and supported by the Israel Ministry of Health. We thank Amichai Ron for his assistance with generating Figures 5 and 7.
Publisher Copyright:
© 2022 Centers for Disease Control and Prevention (CDC). All rights reserved.
PY - 2022/1/1
Y1 - 2022/1/1
N2 - Invasive group A Streptococcus (iGAS) infections have increased in Israel since 2016 as successful lineages have emerged. We report the emergence and outbreak of a multidrug-resistant S. pyogenes emm93.0, sequence type 10, among iGAS infections in Israel since 2017. This type has been observed very rarely in other countries. During this period, emm93.0 was the cause of 116 infections in Israel and became the leading type during 2018. Most of the infections were from bacteremia (75%), and most patients were male (76%). We observed infections across Israel, mainly in adults. Of note, we observed multidrug resistance for clindamycin, tetracycline, and trimethoprim/sulfamethoxazole. Whole-genome sequencing confi rmed clonality among geographically disseminated isolates. The local emm93.0 sequence type 10 clone contained a novel genomic island harboring the resistance genes lsa(E), lnu(B), and ant (6)-Ia aph(3')-III. Further phenotypic and genomic studies are required to determine the prevalence of this resistance element in other iGAS types.
AB - Invasive group A Streptococcus (iGAS) infections have increased in Israel since 2016 as successful lineages have emerged. We report the emergence and outbreak of a multidrug-resistant S. pyogenes emm93.0, sequence type 10, among iGAS infections in Israel since 2017. This type has been observed very rarely in other countries. During this period, emm93.0 was the cause of 116 infections in Israel and became the leading type during 2018. Most of the infections were from bacteremia (75%), and most patients were male (76%). We observed infections across Israel, mainly in adults. Of note, we observed multidrug resistance for clindamycin, tetracycline, and trimethoprim/sulfamethoxazole. Whole-genome sequencing confi rmed clonality among geographically disseminated isolates. The local emm93.0 sequence type 10 clone contained a novel genomic island harboring the resistance genes lsa(E), lnu(B), and ant (6)-Ia aph(3')-III. Further phenotypic and genomic studies are required to determine the prevalence of this resistance element in other iGAS types.
UR - http://www.scopus.com/inward/record.url?scp=85121674467&partnerID=8YFLogxK
U2 - 10.3201/eid2801.210733
DO - 10.3201/eid2801.210733
M3 - Article
C2 - 34932442
AN - SCOPUS:85121674467
SN - 1080-6040
VL - 28
SP - 118
EP - 126
JO - Emerging Infectious Diseases
JF - Emerging Infectious Diseases
IS - 1
ER -
