Invasive Multidrug-Resistant emm93.0 Streptococcus pyogenes Strain Harboring a Novel Genomic Island, Israel, 2017-2019

Merav Ron, Tal Brosh-Nissimov, Zinaida Korenman, Orit Treygerman, Orli Sagi, Lea Valinsky, Assaf Rokney

    Research output: Contribution to journalArticlepeer-review

    5 Scopus citations

    Abstract

    Invasive group A Streptococcus (iGAS) infections have increased in Israel since 2016 as successful lineages have emerged. We report the emergence and outbreak of a multidrug-resistant S. pyogenes emm93.0, sequence type 10, among iGAS infections in Israel since 2017. This type has been observed very rarely in other countries. During this period, emm93.0 was the cause of 116 infections in Israel and became the leading type during 2018. Most of the infections were from bacteremia (75%), and most patients were male (76%). We observed infections across Israel, mainly in adults. Of note, we observed multidrug resistance for clindamycin, tetracycline, and trimethoprim/sulfamethoxazole. Whole-genome sequencing confi rmed clonality among geographically disseminated isolates. The local emm93.0 sequence type 10 clone contained a novel genomic island harboring the resistance genes lsa(E), lnu(B), and ant (6)-Ia aph(3')-III. Further phenotypic and genomic studies are required to determine the prevalence of this resistance element in other iGAS types.

    Original languageEnglish
    Pages (from-to)118-126
    Number of pages9
    JournalEmerging Infectious Diseases
    Volume28
    Issue number1
    DOIs
    StatePublished - 1 Jan 2022

    ASJC Scopus subject areas

    • Microbiology (medical)
    • Infectious Diseases
    • Epidemiology

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