Involvement of the kidneys in Mediterranean spotted fever and murine typhus

Y. Shaked, Y. Samra, O. Shpilberg

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

We reviewed 58 patients, 27 with murine typhus (MT) and 31 with Israeli Mediterranean spotted fever (IMSF), hospitalized at the Sheba Medical Center 1979–1988. Five patients with MT and five with IMSF had evidence of renal impairment. One patient with MT underwent a renal biopsy, and two patients with IMSF died and had autopsy examinations with histology of the kidney. The principal histopathological lesion found in those most severe cases of rickettsiosis-induced renal failure was multifocal perivascular interstitial nephritis. In contrast with previous reports, involvement of the kidneys in rickettsial infection seems to be relatively common. Early diagnosis and treatment with hydration and specific antimicrobial agents is mandatory to prevent morbidity.

Original languageEnglish
Pages (from-to)103-107
Number of pages5
JournalQJM - Monthly Journal of the Association of Physicians
Volume87
Issue number2
DOIs
StatePublished - 1 Jan 1994
Externally publishedYes

ASJC Scopus subject areas

  • General Medicine

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