Ipsilateral breast carcinoma following treatment for primary breast lymphoma

D. B. Geffen, E. Cagnano, M. Tokar, S. Ariad, M. Koretz

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Background: The breast is an unusual site for primary non-Hodgkin's lymphoma. Carcinoma in the same breast after treatment for lymphoma poses therapeutic challenges, but there is only 1 case report in Japanese, which describes this occurrence. Patient and Methods: A 59-year-old woman was diagnosed with infiltrating ductal carcinoma of the breast after receiving doxorubicinand vincristine-based chemotherapy for ipsilateral primary large cell breast lymphoma. The cancer was of high grade histology, with immunohistochemistry staining 3+ positive for HER2/neu. Results: After lumpectomy and sentinel node biopsy, adjuvant paclitaxel without anthracyclines was given but had to be stopped early because of neurotoxicity. Radiotherapy to the breast was administered, and a 1-year course of trastuzumab was planned. Conclusion: Breast cancer can occur after breast lymphoma. For primary breast lymphoma, cumulative doses of cardiotoxic and neurotoxic drugs should be limited to 3-4 cycles of chemotherapy, using treatment protocols for stage I-II large cell lymphoma. Consolidation radiotherapy should be considered at a dose curative for microscopic breast cancer.

Original languageEnglish
Pages (from-to)134-136
Number of pages3
Issue number3
StatePublished - 1 Mar 2007


  • Breast cancer
  • Breast lymphoma, primary
  • Cardiotoxic drugs
  • Chemotherapy
  • Neurotoxic drugs
  • Radiotherapy

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research


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