Irreversible metabolic abnormalities following chronic upper airway loading

Mohammad H. Assadi, Yael Segev, Ariel Tarasiuk

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Study Objectives: Treatment of obstructive sleep apnea increases obesity risk by an unclear mechanism. Here, we explored the effects of upper airway obstruction and its removal on respiratory homeostasis, energy expenditure, and feeding hormones during the sleep/wake cycle from weaning to adulthood. Methods: The tracheas of 22-day-old rats were narrowed, and obstruction removal was performed on post-surgery day 14. Energy expenditure, ventilation, and hormone-regulated feeding were analyzed during 49 days before and after obstruction. Results: Energy expenditure increased and body temperature decreased in upper airway obstruction and was only partially recovered in obstruction removal despite normalization of airway resistance. Increased energy expenditure was associated with upregulation of ventilation. Decreased body temperature was associated with decreased brown adipose tissue uncoupling protein 1 level, suppressed energy expenditure response to norepinephrine, and decreased leptin level. Upper airway obstructed animals added less body weight, in spite of an increase in food intake, due to elevated hypothalamic orexin and neuropeptide Y and plasma ghrelin. Animals who underwent obstruction removal fed more due to an increase in hypothalamic neuropeptide Y and plasma ghrelin. Conclusions: The need to maintain respiratory homeostasis is associated with persistent abnormal energy metabolism and hormonal regulation of feeding. Surgical treatment per se may not be sufficient to correct energy homeostasis, and endocrine regulation of feeding may have a larger effect on weight change.

Original languageEnglish
Article numberzsz176
Issue number12
StatePublished - 1 Dec 2019


  • Energy expenditure
  • Feeding hormones
  • Pediatric OSA
  • Thermogenesis

ASJC Scopus subject areas

  • Clinical Neurology
  • Physiology (medical)


Dive into the research topics of 'Irreversible metabolic abnormalities following chronic upper airway loading'. Together they form a unique fingerprint.

Cite this