Is classical Hodgkin's disease indeed a single entity?

Amalia Levy, Yaron Armon, Jacob Gopas, Samuel Ariad, Isebrand Prinsloo, Ofer Shpilberg, Joseph Kapelushnik, Martin Sacks, Daniel Benharroch

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


We present a retrospective clinicopathological study on the significance of the histologic type of classical Hodgkin's disease (HD) in a cohort of patients from southern Israel. This was performed to critically evaluate the generally accepted view that classical HD is a single clinicopathological entity and the resultant impression that its segregation into four different histologic types remains essential only for the pathologist in his diagnostic endeavor. We confirmed the existence of a uniform response of nodular sclerosis (NS), and mixed cellularity-lymphocyte depletion (MC-LD)-HD to treatment, consideration being given to other classical prognostic factors. We also accept the fact that histological type is not a significant independent factor in terms of survival. Our findings, however, do suggest that NS-HD, on the one hand, and MC-LD-HD, on the other, are distinct biologic entities. Cases of NS differ significantly from those of MC-LD-HD with regard to sex and age distribution, and in the expression of several antigens and gene products, including sialylated-CD15, CD30, LMP1 and the p53 and mdm-2 gene products.

Original languageEnglish
Pages (from-to)1813-1818
Number of pages6
JournalLeukemia and Lymphoma
Issue number9
StatePublished - 23 Aug 2002


  • Classical Hodgkin's disease
  • Lymphoma depletion
  • Mixed cellularity
  • Nodular sclerosis

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research


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