Is fibromyalgia a discrete entity?

Jacob N. Ablin, Dan Buskila, Boudewijn Van Houdenhove, Patrick Luyten, Fabiola Atzeni, Piercarlo Sarzi-Puttini

    Research output: Contribution to journalReview articlepeer-review

    22 Scopus citations


    Fibromyalgia (FM) is defined as chronic widespread pain (CWP) with allodynia or hyperalgesia to pressure pain, and is classified as one of the largest group of soft tissue pain syndromes. Its pathogenesis is not entirely understood, although it is currently believed to be the result of a central nervous system (CNS) malfunction that increases pain transmission and perception. There are no instrumental tests to confirm the diagnosis, but many of the differential diagnoses can be excluded by means of an extensive clinical examination and patient history. Although fibromyalgia is a recognisable clinical entity, it would seem appropriate to consider the entire range of tenderness and distress in clinic patients in order to tailor treatment on an individual basis.

    Original languageEnglish
    Pages (from-to)585-588
    Number of pages4
    JournalAutoimmunity Reviews
    Issue number8
    StatePublished - 1 Jun 2012


    • Chronic fatigue syndrome
    • Fibromyalgia
    • Immune system
    • Sickness behaviour
    • Stress

    ASJC Scopus subject areas

    • Immunology and Allergy
    • Immunology


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