Is gastro-oesophageal reflux a factor in exercise-induced asthma?

P. Weiner, N. Konson, A. Sternberg, D. Zamir, Z. Fireman

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


Exercise-induced bronchoconstriction (EIB) occurs in the majority of patients with asthma. The relationship between asthma and gastro-oesophageal reflux (GER) is well defined, and the reports of exertional gastro-oesophageal acid reflux in healthy subjects, prompted us to study the relationship between EIB and GER. Following an overnight fast and medication withholding, 15 asthmatics and 15 normal subjects were placed on continuous monitoring of oesophageal pH and EGG. After baseline monitoring of oesophageal pH, at rest, for 30 min, spirometry was performed. Thereafter, the subjects underwent rigorous treadmill exercise for 8 min followed by spirometry, 10 min after running. Twelve out of 15 asthmatics and none in the control group demonstrated significant fall in FEV1 in response to exercise. However, only six out of 15 normal subjects and three in the asthmatic group had evidence of GER during or following exercise. We concluded that there is no significant correlation between EIB and GER in patients with asthma.

Original languageEnglish
Pages (from-to)1071-1075
Number of pages5
JournalRespiratory Medicine
Issue number8
StatePublished - 1 Jan 1998
Externally publishedYes

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine


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