Is hypothalamic prostaglandin E2 involved in avian fever?

Vadim Fraifeld; Ronit Blaicher-Kulick; A. Allan Degen; Jacob Kaplanski

doi:10.1016/0024-3205(95)00086-0

Is hypothalamic prostaglandin E₂ involved in avian fever?

Vadim Fraifeld, Ronit Blaicher-Kulick, A. Allan Degen, Jacob Kaplanski

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

In chickens, the effect of Escherichia coli lipopolysaccharide (LPS) on body temperature and ex vivo hypothalamic prostaglandin E₂ (PGE₂) production was examined to test the possible involvement of PGE₂ in mechanisms of avian fever. PGE₂ is reported to be the major central mediator of fever in mammals; it has not been examined in birds. An intraperitoneal injection of LPS caused an elevation of body temperature but not an elevation of hypothalamic PGE₂ production. It seems that: (a) hypothalamic PGE₂ is not involved in the development of the febrile response in birds; (b) central mechanisms of avian fever differ from those in mammals.

Original language	English
Pages (from-to)	1343-1346
Number of pages	4
Journal	Life Sciences
Volume	56
Issue number	16
DOIs	https://doi.org/10.1016/0024-3205(95)00086-0
State	Published - 10 Mar 1995

Keywords

Iipopolysaccharide
avian fever
body temperature
prostaglandin E

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology
General Pharmacology, Toxicology and Pharmaceutics

Access to Document

10.1016/0024-3205(95)00086-0

Cite this

@article{02fffc0b1ba04a4791d134f067725e97,

title = "Is hypothalamic prostaglandin E2 involved in avian fever?",

abstract = "In chickens, the effect of Escherichia coli lipopolysaccharide (LPS) on body temperature and ex vivo hypothalamic prostaglandin E2 (PGE2) production was examined to test the possible involvement of PGE2 in mechanisms of avian fever. PGE2 is reported to be the major central mediator of fever in mammals; it has not been examined in birds. An intraperitoneal injection of LPS caused an elevation of body temperature but not an elevation of hypothalamic PGE2 production. It seems that: (a) hypothalamic PGE2 is not involved in the development of the febrile response in birds; (b) central mechanisms of avian fever differ from those in mammals.",

keywords = "Iipopolysaccharide, avian fever, body temperature, prostaglandin E",

author = "Vadim Fraifeld and Ronit Blaicher-Kulick and Degen, {A. Allan} and Jacob Kaplanski",

note = "Funding Information: This study was partially supportedb y a grantf rom the Centerf or Absorption in Science,t he Ministry for ImmigrantA bsorption, Stateo f Israel. We thankA bdullah Abou-Rachbahf or technical assistancea nd for taking careo f the animalsa nd David Galili for providing the chickens.",

year = "1995",

month = mar,

day = "10",

doi = "10.1016/0024-3205(95)00086-0",

language = "English",

volume = "56",

pages = "1343--1346",

journal = "Life Sciences",

issn = "0024-3205",