Is rate of skin wound healing associated with aging or longevity phenotype?

Hagai Yanai, Arie Budovsky, Robi Tacutu, Vadim E. Fraifeld

Research output: Contribution to journalReview articlepeer-review

25 Scopus citations


Wound healing (WH) is a fundamental biological process. Is it associated with a longevity or aging phenotype? In an attempt to answer this question, we compared the established mouse models with genetically modified life span and also an altered rate of WH in the skin. Our analysis showed that the rate of skin WH in advanced ages (but not in the young animals) may be used as a marker for biological age, i.e., to be indicative of the longevity or aging phenotype. The ability to preserve the rate of skin WH up to an old age appears to be associated with a longevity phenotype, whereas a decline in WH-with an aging phenotype. In the young, this relationship is more complex and might even be inversed. While the aging process is likely to cause wounds to heal slowly, an altered WH rate in younger animals could indicate a different cellular proliferation and/or migration capacity, which is likely to affect other major processes such as the onset and progression of cancer. As a point for future studies on WH and longevity, using only young animals might yield confusing or misleading results, and therefore including older animals in the analysis is encouraged.

Original languageEnglish
Pages (from-to)591-597
Number of pages7
Issue number6
StatePublished - 1 Dec 2011


  • Aging
  • Genes
  • Longevity
  • Mouse models
  • Skin
  • Wound healing

ASJC Scopus subject areas

  • Aging
  • Gerontology
  • Geriatrics and Gerontology


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