Isolated ACTH deficiency and primary hypothyroidism: Volume-dependent elevation of antidiuretic hormone secretion in the presence of hyponatremia

D. Leroith, D. Broitman, S. Sukenik, S. M. Glick

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

The unusual combination of isolated deficiency of ACTH secretion and primary hypothyroidism was demonstrated in a 72-year-old man. Antidiuretic hormone (ADH) levels were elevated despite severe hyponatremia. This abnormality was corrected by salt replacement and hydrocortisone therapy. These results suggest that the elevated ADH levels were appropriate for the volume depletion caused by the hypoadrenalism and were not related to the hypothyroidism.

Original languageEnglish
Pages (from-to)440-443
Number of pages4
JournalIsrael Journal of Medical Sciences
Volume16
Issue number6
StatePublished - 1 Jan 1980
Externally publishedYes

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