Isotonic and isometric responses of blood pressure and heart rate in mild to moderate hypertension with isradipine and propranolol

A. Cantor, N. Cristal

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

The objectives of this study were (a) to evaluate the dose-response eflect of isradipine, a dihydropyridine calcium antagonist, on the heart rate and blood pressure of males with mild to moderate hypertension; and (b) to compare these results with those obtained with propranolol, a β-adrenoceptor blocker, on a matched patient population. Twenty-four patients entered a single-blind study, beginning with a 2-week washout placebo period followed by a forced-titration period. Treadmill and hand-grip tests were also performed. Two weeks were allocated to each stage of the therapy. The end point of the study was normalization of blood pressure with a minimum of side effects. Results and conclusions include the following: both drugs were effective in reducing systolic blood pressure (SBP) and diastolic blood pressure (DBP), but isradipine was more effective in reducing the DBP; isometric exercise can predict accurately the results of the isotonic exercise; the maximum therapeutic effect of propranolol was achieved during the second study-dose level; increases in the isradipine dose were reflected in a proportional reduction of SBP and DBP; and the incidence of side effects is lower among isradipinetreated patients compared to propranolol-treated patients.

Original languageEnglish
Pages (from-to)S75-S78
JournalJournal of Cardiovascular Pharmacology
Volume15
DOIs
StatePublished - 1 Jan 1990
Externally publishedYes

Keywords

  • Hypertension
  • Isometric exercise
  • Isotonic exercise
  • Isradipine
  • Propranolol

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