Isotretinoin in dermatology

B. Amichai; M. H. Grunwald

doi:10.1080/095466300750134214

Isotretinoin in dermatology

B. Amichai, M. H. Grunwald

Faculty of Health Sciences

Research output: Contribution to journal › Review article › peer-review

23 Scopus citations

Abstract

Isotretinoin (13-cis retinoic acid) revolutionized the treatment of acne. Since the early 1980s patients suffering from severe forms of acne have been treated effectively, with less residual cosmetic or psychological damage. OBJECTIVE: The aim of this article is to provide a wide review of isotretinoin, including its clinical applications in dermatology, side effects and drug interactions. DISCUSSION: Isotretinoin affects epidermal cell growth and differentiation as well as sebaceous gland activity, and exhibits immunomodulatory and anti-inflammatory properties, which are important in the treatment of a wide range of other cutaneous diseases - mainly disorders of keratinization and also in proliferative diseases.

Original language	English
Pages (from-to)	219-240
Number of pages	22
Journal	Journal of Dermatological Treatment
Volume	11
Issue number	4
DOIs	https://doi.org/10.1080/095466300750134214
State	Published - 1 Dec 2000

Keywords

Isotretinoin
Side effects
Therapy

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10.1080/095466300750134214

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abstract = "Isotretinoin (13-cis retinoic acid) revolutionized the treatment of acne. Since the early 1980s patients suffering from severe forms of acne have been treated effectively, with less residual cosmetic or psychological damage. OBJECTIVE: The aim of this article is to provide a wide review of isotretinoin, including its clinical applications in dermatology, side effects and drug interactions. DISCUSSION: Isotretinoin affects epidermal cell growth and differentiation as well as sebaceous gland activity, and exhibits immunomodulatory and anti-inflammatory properties, which are important in the treatment of a wide range of other cutaneous diseases - mainly disorders of keratinization and also in proliferative diseases.",

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AU - Grunwald, M. H.

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AB - Isotretinoin (13-cis retinoic acid) revolutionized the treatment of acne. Since the early 1980s patients suffering from severe forms of acne have been treated effectively, with less residual cosmetic or psychological damage. OBJECTIVE: The aim of this article is to provide a wide review of isotretinoin, including its clinical applications in dermatology, side effects and drug interactions. DISCUSSION: Isotretinoin affects epidermal cell growth and differentiation as well as sebaceous gland activity, and exhibits immunomodulatory and anti-inflammatory properties, which are important in the treatment of a wide range of other cutaneous diseases - mainly disorders of keratinization and also in proliferative diseases.

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KW - Side effects

KW - Therapy

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ER -

Isotretinoin in dermatology

Abstract

Keywords

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