Journey of organ on a chip technology and its role in future healthcare scenario

Deepanmol Singh, Ashish Mathur, Smriti Arora, Souradeep Roy, Neeraj Mahindroo

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Organ on a chip refers to microengineered biomimetic system which reflects structural and functional characteristics of human tissue. It involves biomaterial technology, cell biology and engineering combined together in a miniaturized platform. Several models using different organs such as lungs on a chip, liver on a chip, kidney on a chip, heart on a chip, intestine on a chip and skin on a chip have been successfully developed. Food and Drug administration (FDA) has also shown confidence in this technology and has partnered with industries/institutes which are working with this technology. In this review, the concepts and applications of Organ on a chip model in different scientific domains including disease model development, drug screening, toxicology, pathogenesis study, efficacy testing and virology is discussed. It is envisaged that amalgamation of various organs on chip modules into a unified body on chip device is of utmost importance for diagnosis and treatment, especially considering the complications due to the ongoing COVID-19 pandemic. It is expected that the market demand for developing organ on chip devices to skyrocket in the near future.

Original languageEnglish
Article number100246
JournalApplied Surface Science Advances
Volume9
DOIs
StatePublished - 1 Jun 2022
Externally publishedYes

Keywords

  • Body on chip
  • Heart on chip
  • Kidney on chip
  • Liver on chip
  • Microfluidic cell
  • Organ on chip technology

ASJC Scopus subject areas

  • Surfaces and Interfaces
  • Surfaces, Coatings and Films

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